ufsp2 ufm1-specific peptidase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ufsp2provided by ZNC
Official Full Name: ufm1-specific peptidase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-8726
See related: Ensembl:ENSDARG00000056369 AllianceGenome:ZFIN:ZDB-GENE-030131-8726
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb891; fb05c06; fk89d04; zgc:64113; wu:fb05c06; wu:fk89d04
Summary: Predicted to enable deUFMylase activity. Predicted to be involved in proteolysis and ribosome disassembly. Predicted to be located in cytoplasm. Predicted to be active in endoplasmic reticulum and nucleus. Is expressed in hatching gland; myotome; notochord; polster; and segmental plate. Human ortholog(s) of this gene implicated in Beukes hip dysplasia and developmental and epileptic encephalopathy 106. Orthologous to human UFSP2 (UFM1 specific peptidase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (17699471..17711673, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (17006534..17018743, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

G45260 (e-PCR)
- UniSTS:106062

fb05c06.x1 (e-PCR)
- UniSTS:202692

fk89d04.x1 (e-PCR)
- UniSTS:201680

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables deUFMylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables deUFMylase activity	IEA Inferred from Electronic Annotation more info
enables deUFMylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	ISS Inferred from Sequence or Structural Similarity more info
involved_in ribosome disassembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ufm1-specific protease 2

NP_942105.1

EC 3.4.22.-

XP_005168394.1

EC 3.4.22.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198810.1 → NP_942105.1 ufm1-specific protease 2

See identical proteins and their annotated locations for NP_942105.1

Status: PROVISIONAL

Source sequence(s)

BC053257

UniProtKB/Swiss-Prot

Q7T347

Related

ENSDARP00000116873.1, ENSDART00000148322.3

Conserved Domains (1) summary

pfam07910
Location:208 → 393

Peptidase_C78; Peptidase family C78

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007112.7 Reference GRCz11 Primary Assembly

Range

17699471..17711673 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005168337.5 → XP_005168394.1 ufm1-specific protease 2 isoform X1

UniProtKB/TrEMBL

A0A8M2BFM5, B8JIG4

Related

ENSDARP00000110184.2, ENSDART00000122670.4

Conserved Domains (1) summary

pfam07910
Location:273 → 458

Peptidase_C78; Peptidase family C78