Prss45 serine protease 45 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prss45provided by MGI
Official Full Name: serine protease 45provided by MGI
Primary source: MGI:MGI:3605764
See related: Ensembl:ENSMUSG00000047257 AllianceGenome:MGI:3605764
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tespl; Tessp5
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human PRSS45P (serine protease 45, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward testis adult (RPKM 26.5) See more
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Genomic context

Location:: 9 F2; 9 60.79 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (110663656..110670378)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (110834588..110841310)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We identified a testis-specific protease-like protein tentatively named TESPL.
Title: Exclusive expression of a membrane-bound Spink3-interacting serine protease-like protein TESPL in mouse testis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: inactive serine protease 45

Names: inactive testis serine protease 5; protease, serine 45; testis serine protease 5; trypsin-like protease p98

NP_694812.1

EC 3.4.21.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153172.1 → NP_694812.1 inactive serine protease 45 precursor

See identical proteins and their annotated locations for NP_694812.1

Status: PROVISIONAL

Source sequence(s)

AF392062

Consensus CDS

CCDS23575.1

UniProtKB/Swiss-Prot

Q3KNK7, Q8K4D1, Q8K4I7

Related

ENSMUSP00000011391.8, ENSMUST00000011391.12

Conserved Domains (2) summary

smart00020
Location:59 → 286

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:59 → 289

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...