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    Zfp182 zinc finger protein 182 [ Mus musculus (house mouse) ]

    Gene ID: 319535, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp182provided by MGI
    Official Full Name
    zinc finger protein 182provided by MGI
    Primary source
    MGI:MGI:2442220
    See related
    Ensembl:ENSMUSG00000054737 AllianceGenome:MGI:2442220
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf182; 6330583I20Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF182 (zinc finger protein 182). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 2.4), CNS E18 (RPKM 2.3) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp182 in Genome Data Viewer
    Location:
    X A1.3; X 16.55 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (20892423..20928357, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (21026184..21062113, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46888 Neighboring gene ELK1, member of ETS oncogene family Neighboring gene RIKEN cDNA A230072C01 gene Neighboring gene ubiquitously expressed prefoldin like chaperone Neighboring gene STARR-seq mESC enhancer starr_46890 Neighboring gene STARR-seq mESC enhancer starr_46891 Neighboring gene sperm acrosome associated 5 Neighboring gene zinc finger protein 300

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    3. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 182
    Names
    zinc finger protein 21

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013387.2 → NP_001013405.2  zinc finger protein 182

      See identical proteins and their annotated locations for NP_001013405.2

      Status: VALIDATED

      Source sequence(s)
      AK032094, AK045698, AK048587, BB231943, BB574195, BC063066
      Consensus CDS
      CCDS40887.1
      UniProtKB/TrEMBL
      A2AE18
      Related
      ENSMUSP00000110989.3, ENSMUST00000115333.9
      Conserved Domains (3) summary
      smart00349
      Location:8 → 84
      KRAB; krueppel associated box
      COG5048
      Location:233 → 622
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:265 → 285
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001111076.1 → NP_001104546.1  zinc finger protein 182

      See identical proteins and their annotated locations for NP_001104546.1

      Status: VALIDATED

      Source sequence(s)
      AK032094, AK043973, AK045698, AK048587, BB231943, BB574195, BC063066
      Consensus CDS
      CCDS40887.1
      UniProtKB/TrEMBL
      A2AE18
      Related
      ENSMUSP00000045005.6, ENSMUST00000040628.6
      Conserved Domains (3) summary
      smart00349
      Location:8 → 84
      KRAB; krueppel associated box
      COG5048
      Location:233 → 622
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:265 → 285
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      20892423..20928357 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251367.2 → XP_030107227.1  zinc finger protein 182 isoform X3

      UniProtKB/TrEMBL
      A2AE18
      Conserved Domains (3) summary
      smart00349
      Location:8 → 84
      KRAB; krueppel associated box
      COG5048
      Location:233 → 622
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:265 → 285
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_030251369.2 → XP_030107229.1  zinc finger protein 182 isoform X5

      Conserved Domains (2) summary
      COG5048
      Location:113 → 502
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:145 → 165
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_030251365.2 → XP_030107225.1  zinc finger protein 182 isoform X2

      Conserved Domains (3) summary
      smart00349
      Location:43 → 119
      KRAB; krueppel associated box
      COG5048
      Location:268 → 657
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:300 → 320
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_036161979.1 → XP_036017872.1  zinc finger protein 182 isoform X3

      UniProtKB/TrEMBL
      A2AE18
      Conserved Domains (3) summary
      smart00349
      Location:8 → 84
      KRAB; krueppel associated box
      COG5048
      Location:233 → 622
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:265 → 285
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_036161981.1 → XP_036017874.1  zinc finger protein 182 isoform X5

      Conserved Domains (2) summary
      COG5048
      Location:113 → 502
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:145 → 165
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. XM_036161978.1 → XP_036017871.1  zinc finger protein 182 isoform X1

      Related
      ENSMUSP00000110990.2, ENSMUST00000115334.8
      Conserved Domains (3) summary
      smart00349
      Location:63 → 139
      KRAB; krueppel associated box
      COG5048
      Location:288 → 677
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:320 → 340
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. XM_036161980.1 → XP_036017873.1  zinc finger protein 182 isoform X4

      Conserved Domains (3) summary
      smart00349
      Location:5 → 81
      KRAB; krueppel associated box
      COG5048
      Location:230 → 619
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:262 → 282
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P560.1 GenPept UniProtKB/Swiss-Prot:Q6P560

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