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    Babam2 BRISC and BRCA1 A complex member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362704, updated on 3-Dec-2024

    Summary

    Official Symbol
    Babam2provided by RGD
    Official Full Name
    BRISC and BRCA1 A complex member 2provided by RGD
    Primary source
    RGD:735111
    See related
    EnsemblRapid:ENSRNOG00000004364 AllianceGenome:RGD:735111
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable polyubiquitin modification-dependent protein binding activity and tumor necrosis factor receptor binding activity. Predicted to be involved in several processes, including cellular response to ionizing radiation; mitotic G2 DNA damage checkpoint signaling; and positive regulation of DNA repair. Predicted to be located in cytosol and nucleus. Predicted to be part of BRCA1-A complex; BRISC complex; and nuclear ubiquitin ligase complex. Orthologous to human BABAM2 (BRISC and BRCA1 A complex member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 268.8), Heart (RPKM 137.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Babam2 in Genome Data Viewer
    Location:
    6q14
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (30089065..30467508, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (24369021..24788416, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (25666654..26135888, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene PYM homolog 1, exon junction complex associated factor, pseudogene 2 Neighboring gene FOS like 2, AP-1 transcription factor subunit Neighboring gene ribokinase Neighboring gene mitochondrial ribosomal protein L33

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables polyubiquitin modification-dependent protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables polyubiquitin modification-dependent protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables tumor necrosis factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables tumor necrosis factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tumor necrosis factor receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to ionizing radiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in double-strand break repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in double-strand break repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitotic G2 DNA damage checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic G2 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic G2 DNA damage checkpoint signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to ionizing radiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to ionizing radiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of BRCA1-A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of BRCA1-A complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of BRCA1-A complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of BRCA1-A complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of BRISC complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of BRISC complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of BRISC complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of nuclear ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    BRISC and BRCA1-A complex member 2
    Names
    BRCA1-A complex subunit BRE
    BRCA1/BRCA2-containing complex subunit 45
    brain and reproductive organ-expressed (TNFRSF1A modulator)
    brain and reproductive organ-expressed protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199270.2NP_954891.1  BRISC and BRCA1-A complex member 2

      See identical proteins and their annotated locations for NP_954891.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      Q6P7Q1
      UniProtKB/TrEMBL
      A0A8I6A9B7, A6HA33
      Related
      ENSRNOP00000005855.5, ENSRNOT00000005855.6
      Conserved Domains (1) summary
      pfam06113
      Location:8333
      BRE; Brain and reproductive organ-expressed protein (BRE)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      30089065..30467508 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262050.1XP_063118120.1  BRISC and BRCA1-A complex member 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y9T9
    2. XM_039112461.2XP_038968389.1  BRISC and BRCA1-A complex member 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6P7Q1
      UniProtKB/TrEMBL
      A0A8I6A9B7, A6HA33
      Conserved Domains (1) summary
      pfam06113
      Location:8333
      BRE; Brain and reproductive organ-expressed protein (BRE)
    3. XM_039112464.2XP_038968392.1  BRISC and BRCA1-A complex member 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y9T9
    4. XM_006239802.4XP_006239864.1  BRISC and BRCA1-A complex member 2 isoform X1

      See identical proteins and their annotated locations for XP_006239864.1

      UniProtKB/Swiss-Prot
      Q6P7Q1
      UniProtKB/TrEMBL
      A0A8I6A9B7, A6HA33
      Conserved Domains (1) summary
      pfam06113
      Location:8333
      BRE; Brain and reproductive organ-expressed protein (BRE)
    5. XM_039112465.2XP_038968393.1  BRISC and BRCA1-A complex member 2 isoform X4

      Conserved Domains (1) summary
      pfam06113
      Location:1195
      BRE; Brain and reproductive organ-expressed protein (BRE)
    6. XM_039112463.2XP_038968391.1  BRISC and BRCA1-A complex member 2 isoform X2

      Conserved Domains (1) summary
      pfam06113
      Location:15283
      BRE; Brain and reproductive organ-expressed protein (BRE)
    7. XM_039112468.2XP_038968396.1  BRISC and BRCA1-A complex member 2 isoform X4

      Conserved Domains (1) summary
      pfam06113
      Location:1195
      BRE; Brain and reproductive organ-expressed protein (BRE)

    RNA

    1. XR_010052102.1 RNA Sequence

    2. XR_010052101.1 RNA Sequence