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    Eepd1 endonuclease/exonuclease/phosphatase family domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315500, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eepd1provided by RGD
    Official Full Name
    endonuclease/exonuclease/phosphatase family domain containing 1provided by RGD
    Primary source
    RGD:1307401
    See related
    EnsemblRapid:ENSRNOG00000006931 AllianceGenome:RGD:1307401
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307401
    Summary
    Predicted to enable DNA binding activity and catalytic activity. Predicted to be involved in positive regulation of cholesterol efflux. Predicted to be active in plasma membrane. Orthologous to human EEPD1 (endonuclease/exonuclease/phosphatase family domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 1223.6), Muscle (RPKM 336.2) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eepd1 in Genome Data Viewer
    Location:
    8q13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (32233834..32340148)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (23957258..24064343)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (26651241..26758330)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351664 Neighboring gene septin 7 Neighboring gene ribosomal protein S6, pseudogene 5 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC108351840 Neighboring gene uncharacterized LOC134479971

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. EEPD1 Is a Novel LXR Target Gene in Macrophages Which Regulates ABCA1 Abundance and Cholesterol Efflux. Nelson JK, et al. Arterioscler Thromb Vasc Biol, 2017 Mar. PMID 28082258, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC116390

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    endonuclease/exonuclease/phosphatase family domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014088.4 → NP_001014110.1  endonuclease/exonuclease/phosphatase family domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001014110.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q5XI74
      UniProtKB/TrEMBL
      A6JYC0
      Related
      ENSRNOP00000009342.5, ENSRNOT00000009342.7
      Conserved Domains (3) summary
      cd10283
      Location:261 → 538
      MnuA_DNase1-like; Mycoplasma pulmonis MnuA nuclease-like
      COG1555
      Location:43 → 195
      ComEA; DNA uptake protein ComE and related DNA-binding proteins [Replication, recombination and repair]
      pfam12836
      Location:37 → 95
      HHH_3; Helix-hairpin-helix motif

    2. NM_001429804.1 → NP_001416733.1  endonuclease/exonuclease/phosphatase family domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5ZPH9

    RNA

    1. NR_190792.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    2. NR_190793.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    3. NR_190794.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      32233834..32340148
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242727.5 → XP_006242789.1  endonuclease/exonuclease/phosphatase family domain-containing protein 1 isoform X1

      Related
      ENSRNOP00000079888.1, ENSRNOT00000118856.2
      Conserved Domains (3) summary
      cd10283
      Location:261 → 501
      MnuA_DNase1-like; Mycoplasma pulmonis MnuA nuclease-like
      COG1555
      Location:43 → 195
      ComEA; DNA uptake protein ComE and related DNA-binding proteins [Replication, recombination and repair]
      pfam12836
      Location:37 → 95
      HHH_3; Helix-hairpin-helix motif

    2. XM_063265374.1 → XP_063121444.1  endonuclease/exonuclease/phosphatase family domain-containing protein 1 isoform X2

    RNA

    1. XR_010053959.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XI74.1 GenPept UniProtKB/Swiss-Prot:Q5XI74

    Gene LinkOut

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