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    Pdilt protein disulfide isomerase-like, testis expressed [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293544, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pdiltprovided by RGD
    Official Full Name
    protein disulfide isomerase-like, testis expressedprovided by RGD
    Primary source
    RGD:1307822
    See related
    EnsemblRapid:ENSRNOG00000015368 AllianceGenome:RGD:1307822
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307822
    Summary
    Predicted to enable protein disulfide isomerase activity and protein folding chaperone. Predicted to be involved in protein folding. Predicted to act upstream of or within germ cell migration and spermatid development. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Orthologous to human PDILT (protein disulfide isomerase like, testis expressed). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 368.2) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pdilt in Genome Data Viewer
    Location:
    1q35
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (183268812..183562825, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (173837477..173868685, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (189207164..189238796, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene glycoprotein 2 Neighboring gene uromodulin Neighboring gene acyl-CoA synthetase medium-chain family member 5 Neighboring gene acyl-CoA synthetase medium-chain family member 2 Neighboring gene RGD1559600 Neighboring gene acyl-CoA synthetase medium-chain family member 1 Neighboring gene uncharacterized LOC134483776 Neighboring gene acyl-CoA synthetase medium-chain family member 4 Neighboring gene THUMP domain containing 1 Neighboring gene ERI1 exoribonuclease family member 2 Neighboring gene acyl-CoA synthetase medium-chain family member 3 Neighboring gene RNA exonuclease 5 Neighboring gene defective in cullin neddylation 1 domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Protein disulfide isomerase homolog PDILT is required for quality control of sperm membrane protein ADAM3 and male fertility [corrected]. Tokuhiro K, et al. Proc Natl Acad Sci U S A, 2012 Mar 6. PMID 22357757, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein disulfide isomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein folding chaperone ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within germ cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein disulfide-isomerase-like protein of the testis

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013902.1 → NP_001013924.1  protein disulfide-isomerase-like protein of the testis precursor

      See identical proteins and their annotated locations for NP_001013924.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083897
      UniProtKB/Swiss-Prot
      Q5XI02
      UniProtKB/TrEMBL
      A0A8I5ZRI7, A6I8L3
      Related
      ENSRNOP00000020817.4, ENSRNOT00000020817.6
      Conserved Domains (5) summary
      cd02961
      Location:44 → 126
      PDI_a_family; Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI ...
      cd02981
      Location:156 → 225
      PDI_b_family; Protein Disulfide Isomerase (PDIb) family, redox inactive TRX-like domain b; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
      cd02982
      Location:267 → 364
      PDI_b'_family; Protein Disulfide Isomerase (PDIb') family, redox inactive TRX-like domain b'; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
      cd02995
      Location:385 → 486
      PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
      TIGR01130
      Location:44 → 498
      ER_PDI_fam; protein disulfide isomerase, eukaryotic

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      183268812..183562825 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286384.1 → XP_063142454.1  protein disulfide-isomerase-like protein of the testis isoform X2

      UniProtKB/Swiss-Prot
      Q5XI02
      UniProtKB/TrEMBL
      A0A8I5ZRI7, A6I8L3

    2. XM_063286388.1 → XP_063142458.1  protein disulfide-isomerase-like protein of the testis isoform X4

    3. XM_039107614.2 → XP_038963542.1  protein disulfide-isomerase-like protein of the testis isoform X3

      Conserved Domains (1) summary
      TIGR01130
      Location:69 → 457
      ER_PDI_fam; protein disulfide isomerase, eukaryotic

    4. XM_039107611.2 → XP_038963539.1  protein disulfide-isomerase-like protein of the testis isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZRI7
      Conserved Domains (1) summary
      TIGR01130
      Location:69 → 523
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XI02.1 GenPept UniProtKB/Swiss-Prot:Q5XI02

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