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    Fam149b1 family with sequence similarity 149, member B1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289900, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fam149b1provided by RGD
    Official Full Name
    family with sequence similarity 149, member B1provided by RGD
    Primary source
    RGD:1359592
    See related
    EnsemblRapid:ENSRNOG00000006554 AllianceGenome:RGD:1359592
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1359592
    Summary
    Predicted to be involved in cilium assembly and protein localization to cilium. Predicted to be located in cilium. Human ortholog(s) of this gene implicated in Joubert syndrome. Orthologous to human FAM149B1 (family with sequence similarity 149 member B1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 106.4), Lung (RPKM 98.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fam149b1 in Genome Data Viewer
    Location:
    15p16
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (3978377..4016323, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (3929190..3967140, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (4361860..4399746, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 70 Neighboring gene mitochondrial ribosomal protein S16 Neighboring gene DnaJ heat shock protein family (Hsp40) member C9 Neighboring gene ecdysoneless cell cycle regulator Neighboring gene NAD(P) dependent steroid dehydrogenase-like, pseudogene 1 Neighboring gene nudix hydrolase 13 Neighboring gene potassium two pore domain channel subfamily K member 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    primary cilium assembly protein FAM149B1
    Names
    protein FAM149B1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013878.2 → NP_001013900.1  primary cilium assembly protein FAM149B1 isoform 1

      See identical proteins and their annotated locations for NP_001013900.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      Q5PQL8
      UniProtKB/TrEMBL
      A0A8I6AUW2
      Related
      ENSRNOP00000063752.1, ENSRNOT00000065858.4
      Conserved Domains (1) summary
      pfam12516
      Location:22 → 86
      DUF3719; Protein of unknown function (DUF3719)

    2. NM_001401019.1 → NP_001387948.1  primary cilium assembly protein FAM149B1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A0G2JT74, A0A8I6AUW2, A6KKM2
      Related
      ENSRNOP00000068596.1, ENSRNOT00000079812.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      3978377..4016323 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093081.2 → XP_038949009.1  primary cilium assembly protein FAM149B1 isoform X4

      Conserved Domains (1) summary
      pfam12516
      Location:115 → 179
      DUF3719; Protein of unknown function (DUF3719)

    2. XM_017599604.3 → XP_017455093.1  primary cilium assembly protein FAM149B1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZZN3, A6KKM3
      Related
      ENSRNOP00000083597.1, ENSRNOT00000116953.2
      Conserved Domains (1) summary
      pfam12516
      Location:115 → 179
      DUF3719; Protein of unknown function (DUF3719)

    3. XM_039093079.2 → XP_038949007.1  primary cilium assembly protein FAM149B1 isoform X2

      Conserved Domains (1) summary
      pfam12516
      Location:9 → 73
      DUF3719; Protein of unknown function (DUF3719)

    4. XM_063274065.1 → XP_063130135.1  primary cilium assembly protein FAM149B1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5YBR9
      Related
      ENSRNOP00000076592.1, ENSRNOT00000095550.2

    5. XM_063274066.1 → XP_063130136.1  primary cilium assembly protein FAM149B1 isoform X5

      UniProtKB/Swiss-Prot
      Q5PQL8
      UniProtKB/TrEMBL
      A0A8I6AUW2

    6. XM_063274064.1 → XP_063130134.1  primary cilium assembly protein FAM149B1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5YBR9

    7. XM_039093083.2 → XP_038949011.1  primary cilium assembly protein FAM149B1 isoform X7

      UniProtKB/TrEMBL
      A0A8I6GJ53
      Conserved Domains (1) summary
      pfam12516
      Location:115 → 179
      DUF3719; Protein of unknown function (DUF3719)

    8. XM_039093084.2 → XP_038949012.1  primary cilium assembly protein FAM149B1 isoform X9

      UniProtKB/TrEMBL
      A0A8I6GJ53
      Conserved Domains (1) summary
      pfam12516
      Location:115 → 179
      DUF3719; Protein of unknown function (DUF3719)

    9. XM_063274067.1 → XP_063130137.1  primary cilium assembly protein FAM149B1 isoform X7

      UniProtKB/TrEMBL
      A0A8I6GJ53

    10. XM_017599607.3 → XP_017455096.1  primary cilium assembly protein FAM149B1 isoform X8

      UniProtKB/TrEMBL
      A0A8I6GJ53, A6KKM4
      Related
      ENSRNOP00000090775.1, ENSRNOT00000111751.2
      Conserved Domains (1) summary
      pfam12516
      Location:115 → 179
      DUF3719; Protein of unknown function (DUF3719)

    11. XM_017599606.3 → XP_017455095.1  primary cilium assembly protein FAM149B1 isoform X8

      UniProtKB/TrEMBL
      A0A8I6GJ53, A6KKM4
      Conserved Domains (1) summary
      pfam12516
      Location:115 → 179
      DUF3719; Protein of unknown function (DUF3719)

    12. XM_039093082.2 → XP_038949010.1  primary cilium assembly protein FAM149B1 isoform X6

      UniProtKB/TrEMBL
      A0A8I6GJ53
      Conserved Domains (1) summary
      pfam12516
      Location:115 → 179
      DUF3719; Protein of unknown function (DUF3719)

    13. XM_017599605.3 → XP_017455094.1  primary cilium assembly protein FAM149B1 isoform X8

      UniProtKB/TrEMBL
      A0A8I6GJ53, A6KKM4
      Conserved Domains (1) summary
      pfam12516
      Location:115 → 179
      DUF3719; Protein of unknown function (DUF3719)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PQL8.1 GenPept UniProtKB/Swiss-Prot:Q5PQL8

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