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    dcaf-1 DDB1- and CUL4-associated factor homolog 1 [ Caenorhabditis elegans ]

    Gene ID: 177804, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dcaf-1
    Official Full Name
    DDB1- and CUL4-associated factor homolog 1
    Primary source
    WormBase:WBGene00014243
    Locus tag
    CELE_ZK1251.9
    See related
    AllianceGenome:WB:WBGene00014243
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in chromatin remodeling and protein ubiquitination. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human DCAF1 (DDB1 and CUL4 associated factor 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dcaf-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    24
    Sequence:
    Chromosome: IV; NC_003282.8 (9696989..9706723, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Major sperm protein 10/36/56/76 Neighboring gene SKN-1 Dependent Zygotic transcript Neighboring gene Potassium channel domain-containing protein;TWiK family of potassium channels protein 9 Neighboring gene ncRNA Neighboring gene DPH-type MB domain-containing protein;Diphthamide biosynthesis protein 3 Neighboring gene ADP/ATP translocase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Caenorhabditis elegans cullin-RING ubiquitin ligase CRL4DCAF-1 is required for proper germline nucleolus morphology and male development. Rahman MM, et al. Genetics, 2023 Aug 31. PMID 37433110, Free PMC Article
    2. The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing. Kim Y, et al. Genes Dev, 2008 Sep 15. PMID 18794348, Free PMC Article
    3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Caenorhabditis elegans cullin-RING ubiquitin ligase CRL4DCAF-1 is required for proper germline nucleolus morphology and male development.
      Title: The Caenorhabditis elegans cullin-RING ubiquitin ligase CRL4DCAF-1 is required for proper germline nucleolus morphology and male development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DDB1- and CUL4-associated factor homolog 1
    NP_001294003.1
    • Confirmed by transcript evidence
    NP_501725.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9696989..9706723 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069324.6 → NP_501725.2  DDB1- and CUL4-associated factor homolog 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501725.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21106, Q23436
      Conserved Domains (3) summary
      smart00667
      Location:850 → 883
      LisH; Lissencephaly type-1-like homology motif
      COG2319
      Location:1076 → 1329
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:1133 → 1168
      7WD40; WD40 repeat [structural motif]

    2. NM_001307074.3 → NP_001294003.1  DDB1- and CUL4-associated factor homolog 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294003.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AJI4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21106.5

    Gene LinkOut

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