C32B5.7 Peptidase C1A papain C-terminal domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: C32B5.7
Official Full Name: Peptidase C1A papain C-terminal domain-containing protein
Primary source: WormBase:WBGene00016300
Locus tag: CELE_C32B5.7
See related: AllianceGenome:WB:WBGene00016300
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be located in membrane. Predicted to be active in extracellular space and lysosome. Human ortholog(s) of this gene implicated in neuropathy and pycnodysostosis. Orthologous to human CTSK (cathepsin K) and CTSS (cathepsin S). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See C32B5.7 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 5

Sequence:: Chromosome: II; NC_003280.10 (960528..964069)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

C32B5.13 (e-PCR)
- UniSTS:315655

C32B5.16 (e-PCR)
- UniSTS:306756

STS2-105 (e-PCR)
- UniSTS:241770

C32B5.7 (e-PCR)
- UniSTS:313793

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis involved in protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Peptidase C1A papain C-terminal domain-containing protein

NP_001293573.1

Partially confirmed by transcript evidence

NP_001293574.1

Confirmed by transcript evidence

NP_001293575.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

960528..964069

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001306646.3 → NP_001293575.1 Peptidase C1A papain C-terminal domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293575.1

Status: REVIEWED

UniProtKB/TrEMBL

U4PEU2

Conserved Domains (1) summary

cl23744
Location:15 → 73

Peptidase_C1; C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some ...
NM_001306644.3 → NP_001293573.1 Peptidase C1A papain C-terminal domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293573.1

Status: REVIEWED

UniProtKB/TrEMBL

U4PME4

Conserved Domains (1) summary

cd02248
Location:56 → 234

Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...
NM_001306645.3 → NP_001293574.1 Peptidase C1A papain C-terminal domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293574.1

Status: REVIEWED

UniProtKB/TrEMBL

U4PRP9

Conserved Domains (1) summary

cl23744
Location:1 → 147

Peptidase_C1; C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some ...