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    Rho GTPase activation protein (RhoGAP) with PH domain-containing protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832059, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Rho GTPase activation protein (RhoGAP) with PH domain-containing protein
    Primary source
    TAIR:AT5G19390
    Locus tag
    AT5G19390
    See related
    Araport:AT5G19390
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F7K24.140; F7K24_140
    Summary
    Encodes a protein with similarity to REN1, a Rho GTPase activating protein.
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    22
    Sequence:
    Chromosome: 5; NC_003076.8 (6531529..6538557)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene rhodanese-like domain-containing protein / PPIC-type PPIASE domain-containing protein Neighboring gene CRT (chloroquine-resistance transporter)-like transporter 1 Neighboring gene Telomerase activating protein Est1 Neighboring gene ABC-2 type transporter family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Putative RopGAPs impact division plane selection and interact with kinesin-12 POK1. Stöckle D, et al. Nat Plants, 2016 Aug 8. PMID 27501519
    2. A tip-localized RhoGAP controls cell polarity by globally inhibiting Rho GTPase at the cell apex. Hwang JU, et al. Curr Biol, 2008 Dec 23. PMID 19108776, Free PMC Article
    3. Learning the lipid language of plant signalling. van Leeuwen W, et al. Trends Plant Sci, 2004 Aug. PMID 15358268
    4. New functions of the thylakoid membrane proteome of Arabidopsis thaliana revealed by a simple, fast, and versatile fractionation strategy. Peltier JB, et al. J Biol Chem, 2004 Nov 19. PMID 15322131
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_001036827.1
    NM_001036828.2
    NM_121944.3
    NM_180711.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables phosphatidylinositol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell plate formation involved in plant-type cell wall biogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast thylakoid membrane HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with preprophase band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rho GTPase activation protein (RhoGAP) with PH domain-containing protein
    NP_001031904.1
    • Rho GTPase activation protein (RhoGAP) with PH domain; FUNCTIONS IN: Rho GTPase activator activity, phosphoinositide binding; INVOLVED IN: signal transduction; LOCATED IN: chloroplast thylakoid membrane; EXPRESSED IN: guard cell, cultured cell; CONTAINS InterPro DOMAIN/s: Pleckstrin homology-type (InterPro:IPR011993), Rho GTPase activation protein (InterPro:IPR008936), Pleckstrin homology (InterPro:IPR001849), RhoGAP (InterPro:IPR000198); BEST Arabidopsis thaliana protein match is: Rho GTPase activation protein (RhoGAP) with PH domain (TAIR:AT5G12150.2); Has 4537 Blast hits to 4371 proteins in 246 species: Archae - 4; Bacteria - 47; Metazoa - 3286; Fungi - 432; Plants - 222; Viruses - 0; Other Eukaryotes - 546 (source: NCBI BLink).
    NP_001031905.1
    • Rho GTPase activation protein (RhoGAP) with PH domain; FUNCTIONS IN: Rho GTPase activator activity, phosphoinositide binding; INVOLVED IN: signal transduction; LOCATED IN: chloroplast thylakoid membrane; EXPRESSED IN: guard cell, cultured cell; CONTAINS InterPro DOMAIN/s: Pleckstrin homology-type (InterPro:IPR011993), Rho GTPase activation protein (InterPro:IPR008936), Pleckstrin homology (InterPro:IPR001849), RhoGAP (InterPro:IPR000198); BEST Arabidopsis thaliana protein match is: Rho GTPase activation protein (RhoGAP) with PH domain (TAIR:AT5G12150.2); Has 4185 Blast hits to 4168 proteins in 202 species: Archae - 0; Bacteria - 9; Metazoa - 3193; Fungi - 416; Plants - 210; Viruses - 0; Other Eukaryotes - 357 (source: NCBI BLink).
    NP_197440.2
    • Rho GTPase activation protein (RhoGAP) with PH domain; FUNCTIONS IN: Rho GTPase activator activity, phosphoinositide binding; INVOLVED IN: signal transduction; LOCATED IN: chloroplast thylakoid membrane; EXPRESSED IN: guard cell, cultured cell; CONTAINS InterPro DOMAIN/s: Pleckstrin homology-type (InterPro:IPR011993), Rho GTPase activation protein (InterPro:IPR008936), Pleckstrin homology (InterPro:IPR001849), RhoGAP (InterPro:IPR000198); BEST Arabidopsis thaliana protein match is: Rho GTPase activation protein (RhoGAP) with PH domain (TAIR:AT5G12150.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_851042.2
    • Rho GTPase activation protein (RhoGAP) with PH domain; FUNCTIONS IN: Rho GTPase activator activity, phosphoinositide binding; INVOLVED IN: signal transduction; LOCATED IN: chloroplast thylakoid membrane; EXPRESSED IN: guard cell, cultured cell; CONTAINS InterPro DOMAIN/s: Pleckstrin homology-type (InterPro:IPR011993), Rho GTPase activation protein (InterPro:IPR008936), Pleckstrin homology (InterPro:IPR001849), RhoGAP (InterPro:IPR000198); BEST Arabidopsis thaliana protein match is: Rho GTPase activation protein (RhoGAP) with PH domain (TAIR:AT5G12150.1); Has 4617 Blast hits to 4464 proteins in 264 species: Archae - 6; Bacteria - 65; Metazoa - 3342; Fungi - 447; Plants - 223; Viruses - 0; Other Eukaryotes - 534 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      6531529..6538557
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121944.3 → NP_197440.2  Rho GTPase activation protein (RhoGAP) with PH domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197440.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DFY3, F4K143, Q3E9B9, Q8RWQ4
      UniProtKB/TrEMBL
      A0A178UH09
      Conserved Domains (4) summary
      smart00233
      Location:19 → 125
      PH; Pleckstrin homology domain
      pfam00169
      Location:19 → 125
      PH; PH domain
      pfam00620
      Location:176 → 313
      RhoGAP; RhoGAP domain
      pfam14389
      Location:610 → 689
      Lzipper-MIP1; Leucine-zipper of ternary complex factor MIP1

    2. NM_180711.2 → NP_851042.2  Rho GTPase activation protein (RhoGAP) with PH domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851042.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DFY3, F4K143, Q3E9B9, Q8RWQ4
      UniProtKB/TrEMBL
      A0A178UH09
      Conserved Domains (4) summary
      smart00233
      Location:19 → 125
      PH; Pleckstrin homology domain
      pfam00169
      Location:19 → 125
      PH; PH domain
      pfam00620
      Location:176 → 313
      RhoGAP; RhoGAP domain
      pfam14389
      Location:610 → 689
      Lzipper-MIP1; Leucine-zipper of ternary complex factor MIP1

    3. NM_001036827.1 → NP_001031904.1  Rho GTPase activation protein (RhoGAP) with PH domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031904.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UH09, F4K142
      Conserved Domains (4) summary
      smart00233
      Location:19 → 125
      PH; Pleckstrin homology domain
      pfam00169
      Location:19 → 125
      PH; PH domain
      pfam00620
      Location:176 → 313
      RhoGAP; RhoGAP domain
      pfam14389
      Location:610 → 689
      Lzipper-MIP1; Leucine-zipper of ternary complex factor MIP1

    4. NM_001036828.2 → NP_001031905.1  Rho GTPase activation protein (RhoGAP) with PH domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031905.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UH09
      Conserved Domains (4) summary
      smart00233
      Location:19 → 125
      PH; Pleckstrin homology domain
      pfam00169
      Location:19 → 125
      PH; PH domain
      pfam00620
      Location:176 → 313
      RhoGAP; RhoGAP domain
      pfam14389
      Location:610 → 689
      Lzipper-MIP1; Leucine-zipper of ternary complex factor MIP1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8RWQ4.1

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