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    Pink1 PTEN-induced putative kinase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31607, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pink1provided by FlyBase
    Official Full Name
    PTEN-induced putative kinase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0029891
    Locus tag
    Dmel_CG4523
    See related
    AllianceGenome:FB:FBgn0029891
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:GH23468; CG4523; Dmel\CG4523; dpink; dPink1; dPINk1; dPINK1; Pink; PINK-1; pink1; PINK1
    Summary
    Enables ATP-dependent protein binding activity and protein serine/threonine kinase activity. Involved in several processes, including memory; mitochondrion organization; and regulation of mitochondrion organization. Located in Nebenkern; cytosol; and mitochondrion. Is active in mitochondrial outer membrane. Is expressed in organism. Used to study Hirschsprung's disease; Parkinson's disease; Parkinson's disease 6; early-onset Parkinson's disease; and testicular cancer. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 6. Orthologous to human PINK1 (PTEN induced kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pink1 in Genome Data Viewer
    Location:
    6C6-6C6; 1-18 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6683798..6687302)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6577831..6581335)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase (ubiquinone) ASHI subunit Neighboring gene Fumarase 1 Neighboring gene Fumarase 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in compound eye development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ectopic germ cell programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of mitochondrion localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of protein localization to mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular distribution of mitochondria IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in medium-term memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrial fission IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of mitochondrion inheritance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrion organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitochondrion organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrion transport along microtubule IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitophagy IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in mitophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cytoplasmic translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of mitochondrial fusion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of mitochondrial fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuromuscular synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-serine autophosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of autophagy of mitochondrion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of autophagy of mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of compound eye pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mitochondrial fission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of mitochondrial fission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neuronal action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of mitochondrial electron transport, NADH to ubiquinone IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in reticulophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in short-term memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sperm mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Nebenkern IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    PTEN-induced putative kinase 1
    Names
    CG4523-PA
    CG4523-PB
    CG4523-PC
    CG4523-PD
    CG4523-PE
    CG4523-PF
    CG4523-PG
    CG4523-PH
    CG4523-PI
    PINK1
    PTEN induced putative kinase 1
    PTEN-induced kinase 1
    Pink1-PA
    Pink1-PB
    Pink1-PC
    Pink1-PD
    Pink1-PE
    Pink1-PF
    Pink1-PG
    Pink1-PH
    Pink1-PI
    Pten-induced kinase 1(PINK1)
    ortholog of PINK1
    phosphatase and tensin homolog-induced putative kinase 1
    pink
    NP_001027049.1
    NP_001027050.1
    NP_001027051.1
    NP_001027052.1
    NP_001027053.1
    NP_001027054.1
    NP_001284952.1
    NP_572340.2
    NP_727110.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6683798..6687302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001031878.2NP_001027049.1  PTEN-induced putative kinase 1, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027049.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0KHV6, Q961J3
      Conserved Domains (1) summary
      cd14018
      Location:328639
      STKc_PINK1; Catalytic domain of the Serine/Threonine protein kinase, Pten INduced Kinase 1
    2. NM_001031880.3NP_001027051.1  PTEN-induced putative kinase 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027051.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0KHV6, Q961J3
      Conserved Domains (1) summary
      cd14018
      Location:328639
      STKc_PINK1; Catalytic domain of the Serine/Threonine protein kinase, Pten INduced Kinase 1
    3. NM_001031879.3NP_001027050.1  PTEN-induced putative kinase 1, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027050.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0KHV6, Q961J3
      Conserved Domains (1) summary
      cd14018
      Location:328639
      STKc_PINK1; Catalytic domain of the Serine/Threonine protein kinase, Pten INduced Kinase 1
    4. NM_001031881.3NP_001027052.1  PTEN-induced putative kinase 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027052.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0KHV6, Q961J3
      Conserved Domains (1) summary
      cd14018
      Location:328639
      STKc_PINK1; Catalytic domain of the Serine/Threonine protein kinase, Pten INduced Kinase 1
    5. NM_001031883.3NP_001027054.1  PTEN-induced putative kinase 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027054.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0KHV6, Q961J3
      Conserved Domains (1) summary
      cd14018
      Location:328639
      STKc_PINK1; Catalytic domain of the Serine/Threonine protein kinase, Pten INduced Kinase 1
    6. NM_132112.5NP_572340.2  PTEN-induced putative kinase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572340.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0KHV6, Q961J3
      Related
      FBpp0070917
      Conserved Domains (1) summary
      cd14018
      Location:328639
      STKc_PINK1; Catalytic domain of the Serine/Threonine protein kinase, Pten INduced Kinase 1
    7. NM_167083.4NP_727110.1  PTEN-induced putative kinase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727110.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0KHV6, Q961J3
      Related
      FBpp0070918
      Conserved Domains (1) summary
      cd14018
      Location:328639
      STKc_PINK1; Catalytic domain of the Serine/Threonine protein kinase, Pten INduced Kinase 1
    8. NM_001031882.3NP_001027053.1  PTEN-induced putative kinase 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027053.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0KHV6, Q961J3
      Conserved Domains (1) summary
      cd14018
      Location:328639
      STKc_PINK1; Catalytic domain of the Serine/Threonine protein kinase, Pten INduced Kinase 1
    9. NM_001298023.1NP_001284952.1  PTEN-induced putative kinase 1, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284952.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0KHV6, Q961J3
      Conserved Domains (1) summary
      cd14018
      Location:328639
      STKc_PINK1; Catalytic domain of the Serine/Threonine protein kinase, Pten INduced Kinase 1