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    Rbp2 retinol binding protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24710, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rbp2provided by RGD
    Official Full Name
    retinol binding protein 2provided by RGD
    Primary source
    RGD:3544
    See related
    AllianceGenome:RGD:3544
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables retinol binding activity. Predicted to be involved in fatty acid transport. Predicted to be active in cytosol and nucleus. Orthologous to human RBP2 (retinol binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 16.0), Liver (RPKM 7.5) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rbp2 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (107958670..107983850)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (99079293..99104489)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (106479253..106527726)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene nicotinamide nucleotide adenylyltransferase 3 Neighboring gene retinol binding protein 1 Neighboring gene NME/NM23 nucleoside diphosphate kinase 2, pseudogene 8 Neighboring gene COPI coat complex subunit beta 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The structure and dynamics of rat apo-cellular retinol-binding protein II in solution: comparison with the X-ray structure. Lu J, et al. J Mol Biol, 1999 Mar 5. PMID 10047490
    2. Purification, primary structure characterization, and cellular distribution of two forms of cellular retinol-binding protein, type II from adult rat small intestine. Schaefer WH, et al. J Biol Chem, 1989 Mar 5. PMID 2645288
    3. Rat cellular retinol-binding protein II: use of a cloned cDNA to define its primary structure, tissue-specific expression, and developmental regulation. Li E, et al. Proc Natl Acad Sci U S A, 1986 Aug. PMID 3461459, Free PMC Article
    4. Crystal structures of holo and apo-cellular retinol-binding protein II. Winter NS, et al. J Mol Biol, 1993 Apr 20. PMID 8487303
    5. Genetic isolation of a region of chromosome 8 that exerts major effects on blood pressure and cardiac mass in the spontaneously hypertensive rat. Kren V, et al. J Clin Invest, 1997 Feb 15. PMID 9045857, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that, as compared to controls, CrbpII expression in liver is up-regulated by pregnancy and further increased by iron deficiency; maternal iron deficiency has little impact on vitamin A levels and gene expression in placenta, but increases retinol storage in fetal liver; regulation of CrbpII expression in liver may play important roles in vitamin A metabolism in pregnant females and in fetal development.
      Title: Pregnancy and maternal iron deficiency stimulate hepatic CRBPII expression in rats.
    2. These results suggest that the elevated mRNA expression levels of Rbp2 and Apoa4 in the rats with SB contribute to the effective esterification and transport of vitamin A.
      Title: Massive bowel resection upregulates the intestinal mRNA expression levels of cellular retinol-binding protein II and apolipoprotein A-IV and alters the intestinal vitamin A status in rats.
    3. protein-ligand interaction differences between CRBP-I and CRBP-II
      Title: New insights on the protein-ligand interaction differences between the two primary cellular retinol carriers.
    4. results suggest that CRBPII gene expression during the perinatal period is associated with abrupt acetylation of histones H3 and H4 followed by the binding of CBP/p300 and RXRalpha.
      Title: Induction of histone acetylation on the CRBPII gene in perinatal rat small intestine.
    5. analysis of conformational flexibility of rat cellular retinol-binding protein I (CRBP I) and cellular retinol-binding protein II (CRBP II)
      Title: Two homologous rat cellular retinol-binding proteins differ in local conformational flexibility.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables fatty acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables retinal binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables retinol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables retinol binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retinol metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    retinol-binding protein 2
    Names
    CRBP-II
    Retinol-binding protein 2, cellular
    cellular retinol-binding protein II
    retinol binding protein 2, cellular

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012640.2 → NP_036772.2  retinol-binding protein 2

      See identical proteins and their annotated locations for NP_036772.2

      Status: VALIDATED

      Source sequence(s)
      CN542437, M13949
      UniProtKB/Swiss-Prot
      P06768
      UniProtKB/TrEMBL
      A6I2B3
      Conserved Domains (1) summary
      cd19463
      Location:4 → 134
      CRBP2; cellular retinol-binding protein 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      107958670..107983850
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243607.3 → XP_006243669.1  retinol-binding protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006243669.1

      UniProtKB/Swiss-Prot
      P06768
      UniProtKB/TrEMBL
      A6I2B3
      Conserved Domains (1) summary
      cd19463
      Location:4 → 134
      CRBP2; cellular retinol-binding protein 2

    2. XM_039080832.2 → XP_038936760.1  retinol-binding protein 2 isoform X1

      UniProtKB/Swiss-Prot
      P06768
      UniProtKB/TrEMBL
      A6I2B3
      Conserved Domains (1) summary
      cd19463
      Location:4 → 134
      CRBP2; cellular retinol-binding protein 2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06768.3 GenPept UniProtKB/Swiss-Prot:P06768

    Gene LinkOut

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