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    Mmp1b matrix metallopeptidase 1b (interstitial collagenase) [ Mus musculus (house mouse) ]

    Gene ID: 83996, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mmp1bprovided by MGI
    Official Full Name
    matrix metallopeptidase 1b (interstitial collagenase)provided by MGI
    Primary source
    MGI:MGI:1933847
    See related
    Ensembl:ENSMUSG00000041620 AllianceGenome:MGI:1933847
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mcolb; MMP-1b; Mcol-B
    Summary
    This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Mmp1b in Genome Data Viewer
    Location:
    9 A1; 9 2.46 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (7367670..7388026, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (7367670..7388026, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 13 Neighboring gene STARR-seq mESC enhancer starr_23207 Neighboring gene STARR-seq mESC enhancer starr_23208 Neighboring gene STARR-seq mESC enhancer starr_23209 Neighboring gene STARR-seq mESC enhancer starr_23210 Neighboring gene matrix metallopeptidase 12 Neighboring gene STARR-seq mESC enhancer starr_23211 Neighboring gene STARR-seq mESC enhancer starr_23213 Neighboring gene matrix metallopeptidase 3 Neighboring gene matrix metallopeptidase 1a (interstitial collagenase)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of extracellular matrix metalloproteinase inducer and matrix metalloproteinases during mouse embryonic development. Chen L, et al. Reproduction, 2007 Feb. PMID 17307908
    2. Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation. Balbín M, et al. J Biol Chem, 2001 Mar 30. PMID 11113146
    3. Activating enhancer binding protein 2 epsilon (AP-2ε)-deficient mice exhibit increased matrix metalloproteinase 13 expression and progressive osteoarthritis development. Niebler S, et al. Arthritis Res Ther, 2015 May 12. PMID 25964075, Free PMC Article
    4. Differential expression of tissue inhibitor of metalloproteinases type 1 (TIMP-1) during mouse gonad development. Guyot R, et al. Dev Dyn, 2003 Jul. PMID 12815621
    5. Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice. Wang X, et al. Proc Natl Acad Sci U S A, 2005 Nov 1. PMID 16236725, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to UV-A ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in collagen catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in collagen catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    interstitial collagenase B
    Names
    collagenase-like B
    matrix metalloproteinase 1b (interstitial collagenase)
    NP_114396.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032007.4 → NP_114396.3  interstitial collagenase B preproprotein

      See identical proteins and their annotated locations for NP_114396.3

      Status: VALIDATED

      Source sequence(s)
      AC169512
      Consensus CDS
      CCDS22805.1
      UniProtKB/Swiss-Prot
      Q9EPL6
      UniProtKB/TrEMBL
      G5E8A9
      Related
      ENSMUSP00000047261.8, ENSMUST00000047888.8
      Conserved Domains (4) summary
      cd00094
      Location:273 → 463
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      cd04278
      Location:105 → 259
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam00413
      Location:105 → 259
      Peptidase_M10; Matrixin
      pfam01471
      Location:28 → 84
      PG_binding_1; Putative peptidoglycan binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      7367670..7388026 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EPL6.1 GenPept UniProtKB/Swiss-Prot:Q9EPL6

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