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    Gimap5 GTPase, IMAP family member 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246774, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gimap5provided by RGD
    Official Full Name
    GTPase, IMAP family member 5provided by RGD
    Primary source
    RGD:628871
    See related
    EnsemblRapid:ENSRNOG00000008416 AllianceGenome:RGD:628871
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    lyp; IAN4; Ian5; Ian4l1
    Summary
    Predicted to enable GTP binding activity. Involved in several processes, including mononuclear cell differentiation; positive regulation of lymphocyte mediated immunity; and regulation of T cell activation. Predicted to be located in lysosomal membrane; mitochondrion; and multivesicular body membrane. Used to study lymphopenia and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in portal hypertension. Orthologous to human GIMAP5 (GTPase, IMAP family member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 123.9), Lung (RPKM 62.0) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gimap5 in Genome Data Viewer
    Location:
    4q24
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (79025151..79031917)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (77693417..77701025)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (78377228..78386683)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene GTPase, IMAP family member 7 Neighboring gene GTPase, IMAP family member 1 Neighboring gene transmembrane protein 176B Neighboring gene transmembrane protein 176A Neighboring gene amine oxidase, copper containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Impaired post-thymic development of regulatory CD4+25+ T cells contributes to diabetes pathogenesis in BB rats. Poussier P, et al. J Immunol, 2005 Apr 1. PMID 15778366
    2. The lymphopenia (lyp) gene controls the intrathymic cytokine ratio in congenic BioBreeding rats. Bieg S, et al. Diabetologia, 1997 Jul. PMID 9243099
    3. Excessive production of nitric oxide by macrophages from DP-BB rats is secondary to the T-lymphopenic state of these animals. Lau A, et al. Diabetes, 1998 Feb. PMID 9519713
    4. A diabetogenic gene prevents T cells from receiving costimulatory signals. Moore JK, et al. Cell Immunol, 1999 May 25. PMID 10357884
    5. The antibody response to bacteriophage is linked to the lymphopenia gene in congenic BioBreeding rats. Clark L, et al. FEMS Immunol Med Microbiol, 2002 Feb 18. PMID 11934565

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings confirm a critical albeit differential role of T-cell lymphopenia in the susceptibility to organ-specific autoimmune responses.
      Title: Distinct roles of T-cell lymphopenia and the microbial flora for gastrointestinal and CNS autoimmunity.
    2. functional Gimap5 is required for optimal signaling through TCR and IL-7R in T cells.
      Title: TCR and IL-7 Signaling Are Altered in the Absence of Functional GTPase of the Immune Associated Nucleotide Binding Protein 5 (GIMAP5).
    3. Data indicate that reduced Ca2+ influx in GTPase of the immune-associated nucleotide-binding protein 5 (GIMAP5)-deficient T-cells is associated with the inability of their mitochondria to sequester Ca2+ following capacitative entry.
      Title: GTPase of the immune-associated nucleotide-binding protein 5 (GIMAP5) regulates calcium influx in T-lymphocytes by promoting mitochondrial calcium accumulation.
    4. results suggest that lack of the Gimap5 protein in the DR.(lyp/lyp) congenic rat was associated with impaired expression of the entire family of Gimap genes and may regulate T cell homeostasis in the peripheral lymphoid organs.
      Title: BB rat Gimap gene expression in sorted lymphoid T and B cells.
    5. Obesity and type 2 diabetes in the BioBreeding diabetes-resistant (BBDR) rat result in islet expansion associated with protection from T1D in female but not male BBDR(lepr-/lepr-,Gimap5-/Gimap5-) congenic rats.
      Title: Differential effects of leptin receptor mutation on male and female BBDR Gimap5-/Gimap5- spontaneously diabetic rats.
    6. results show that spontaneous type 1 diabetes is controlled by at least two genetic loci 7 Mb apart on rat chromosome 4
      Title: Genetic dissection reveals diabetes loci proximal to the gimap5 lymphopenia gene.
    7. GIMAP5 is an important regulator of calcium response in T lymphocytes and impaired calcium signaling might underlie spontaneous apoptosis of gimap5(lyp/lyp) T cells.
      Title: Loss of GIMAP5 (GTPase of immunity-associated nucleotide binding protein 5) impairs calcium signaling in rat T lymphocytes.
    8. Knockdown of CHOP by siRNA protected Gimap5(-/-) T cells from endoplasmic reticulum stress-induced apoptosis.
      Title: CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells.
    9. These findings suggest that GIMAP5 regulates T lymphocyte survival by mechanisms that operate upstream of mitochondria.
      Title: GIMAP5 regulates mitochondrial integrity from a distinct subcellular compartment.
    10. Ian4 is a tissue-specific regulator of mitochondrial integrity and is required for T cell survival
      Title: Ian4 is required for mitochondrial integrity and T cell survival.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell differentiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in T cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in myeloid dendritic cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of T cell activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of lipid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of nitric oxide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of type II interferon production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of calcium ion transport into cytosol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gamma-delta T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of humoral immune response mediated by circulating immunoglobulin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of natural killer cell cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of natural killer cell mediated cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitochondrial membrane permeability IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in temperature homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in multivesicular body membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GTPase IMAP family member 5
    Names
    IAN-4
    immune associated nucleotide 4 like 1
    immunity-associated nucleotide 4 protein
    immunity-associated nucleotide 4-like 1 protein
    lymphopenia

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033913.1 → NP_001029085.1  GTPase IMAP family member 5 isoform 1

      See identical proteins and their annotated locations for NP_001029085.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AY550018
      UniProtKB/Swiss-Prot
      Q5YEJ2, Q5YEJ3, Q8K3L6, Q8K3L7
      UniProtKB/TrEMBL
      A6K0I1
      Related
      ENSRNOP00000072663.2, ENSRNOT00000084927.3
      Conserved Domains (2) summary
      cd01852
      Location:45 → 245
      AIG1; AvrRpt2-Induced Gene 1 (AIG1)
      cl21455
      Location:14 → 66
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_145680.3 → NP_663713.1  GTPase IMAP family member 5 isoform 2

      See identical proteins and their annotated locations for NP_663713.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region, compared to variant 1, that results in the use of an upstream start codon. It encodes isoform 2 which has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AY055776, AY550018
      UniProtKB/TrEMBL
      Q0R3W7
      Conserved Domains (1) summary
      cd01852
      Location:27 → 227
      AIG1; AvrRpt2-Induced Gene 1 (AIG1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      79025151..79031917
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236458.5 → XP_006236520.1  GTPase IMAP family member 5 isoform X1

      See identical proteins and their annotated locations for XP_006236520.1

      UniProtKB/TrEMBL
      Q0R3W7
      Conserved Domains (1) summary
      cd01852
      Location:27 → 227
      AIG1; AvrRpt2-Induced Gene 1 (AIG1)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K3L6.1 GenPept UniProtKB/Swiss-Prot:Q8K3L6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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