U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    TEKT4 tektin 4 [ Homo sapiens (human) ]

    Gene ID: 150483, updated on 27-Nov-2024

    Summary

    Official Symbol
    TEKT4provided by HGNC
    Official Full Name
    tektin 4provided by HGNC
    Primary source
    HGNC:HGNC:31012
    See related
    Ensembl:ENSG00000163060 AllianceGenome:HGNC:31012
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be involved in cilium assembly and flagellated sperm motility. Predicted to act upstream of with a positive effect on regulation of brood size. Located in axonemal microtubule. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis (RPKM 2.0), thyroid (RPKM 0.6) and 1 other tissue See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TEKT4 in Genome Data Viewer
    Location:
    2q11.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (94871430..94876823)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (95377957..95383351)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (95537175..95542568)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 20 family member A8, pseudogene Neighboring gene RNA, U6 small nuclear 1320, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:95535972-95536485 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:95536999-95537512 Neighboring gene SOWAHC pseudogene 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:95539413-95540274 Neighboring gene uncharacterized LOC442028 Neighboring gene MT-CO1 pseudogene 48 Neighboring gene MT-CO3 pseudogene 45

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC27019

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in flagellated sperm motility ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in axonemal A tubule inner sheath ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in axonemal microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axonemal microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus HDA PubMed 
    is_active_in sperm flagellum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in sperm flagellum ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    tektin-4
    Names
    epididymis secretory sperm binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286559.2NP_001273488.1  tektin-4 isoform 2

      See identical proteins and their annotated locations for NP_001273488.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site and initiates translation from a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC097374, AK097438
      Related
      ENST00000468063.1
      Conserved Domains (1) summary
      pfam03148
      Location:2241
      Tektin; Tektin family
    2. NM_144705.4NP_653306.1  tektin-4 isoform 1

      See identical proteins and their annotated locations for NP_653306.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC097374, BC021716, BI832036
      Consensus CDS
      CCDS2005.1
      UniProtKB/Swiss-Prot
      Q8WW24
      UniProtKB/TrEMBL
      A0A384MEB7
      Related
      ENSP00000295201.4, ENST00000295201.5
      Conserved Domains (1) summary
      pfam03148
      Location:44423
      Tektin; Tektin family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      94871430..94876823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510670.3XP_011508972.1  tektin-4 isoform X1

      Conserved Domains (1) summary
      pfam03148
      Location:44464
      Tektin; Tektin family
    2. XM_005263876.4XP_005263933.1  tektin-4 isoform X2

      Conserved Domains (1) summary
      pfam03148
      Location:44312
      Tektin; Tektin family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      95377957..95383351
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340654.1XP_054196629.1  tektin-4 isoform X1

    2. XM_054340655.1XP_054196630.1  tektin-4 isoform X2