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    Mcur1 mitochondrial calcium uniporter regulator 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291034, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mcur1provided by RGD
    Official Full Name
    mitochondrial calcium uniporter regulator 1provided by RGD
    Primary source
    RGD:1307673
    See related
    AllianceGenome:RGD:1307673
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ccdc90a; RGD1307673
    Summary
    Predicted to be involved in calcium import into the mitochondrion; calcium ion import; and positive regulation of mitochondrial calcium ion concentration. Predicted to be active in mitochondrial inner membrane. Orthologous to human MCUR1 (mitochondrial calcium uniporter regulator 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 106.1), Thymus (RPKM 55.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mcur1 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (21348490..21365614)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (21142526..21159651)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (24165259..24182425, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 182 Neighboring gene solute carrier family 25 member 31, pseudogene 1 Neighboring gene uncharacterized LOC134482833 Neighboring gene uncharacterized LOC120097874 Neighboring gene RAN binding protein 9 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MCUR1, CCDC90A, Is a Regulator of the Mitochondrial Calcium Uniporter. Vais H, et al. Cell Metab, 2015 Oct 6. PMID 26445506, Free PMC Article
    2. MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism. Mallilankaraman K, et al. Nat Cell Biol, 2012 Dec. PMID 23178883, Free PMC Article
    3. MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics. Tomar D, et al. Cell Rep, 2016 May 24. PMID 27184846, Free PMC Article
    4. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in calcium import into the mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium import into the mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in calcium ion import ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitochondrial calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mitochondrial calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitochondrial calcium uniporter regulator 1
    Names
    coiled-coil domain containing 90A
    coiled-coil domain-containing protein 90A, mitochondrial
    NP_001292107.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305178.1 → NP_001292107.1  mitochondrial calcium uniporter regulator 1

      See identical proteins and their annotated locations for NP_001292107.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A6J744
      Conserved Domains (1) summary
      pfam07798
      Location:143 → 334
      DUF1640; Protein of unknown function (DUF1640)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      21348490..21365614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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