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    Mon2 MON2 homolog, regulator of endosome to Golgi trafficking [ Mus musculus (house mouse) ]

    Gene ID: 67074, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mon2provided by MGI
    Official Full Name
    MON2 homolog, regulator of endosome to Golgi traffickingprovided by MGI
    Primary source
    MGI:MGI:1914324
    See related
    Ensembl:ENSMUSG00000034602 AllianceGenome:MGI:1914324
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sf21; mKIAA1040; 2610528O22Rik
    Summary
    Predicted to be involved in Golgi to endosome transport. Predicted to be located in early endosome membrane. Orthologous to human MON2 (MON2 homolog, regulator of endosome-to-Golgi trafficking). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 7.0), genital fat pad adult (RPKM 6.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mon2 in Genome Data Viewer
    Location:
    10 D2; 10 72.15 cM
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (122827965..122913684, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (122992060..123076505, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1H (PP2C domain containing) Neighboring gene STARR-seq mESC enhancer starr_28140 Neighboring gene predicted gene, 51818 Neighboring gene STARR-positive B cell enhancer ABC_E8375 Neighboring gene STARR-positive B cell enhancer ABC_E5196 Neighboring gene STARR-positive B cell enhancer ABC_E9356 Neighboring gene STARR-positive B cell enhancer ABC_E10651 Neighboring gene microRNA let7i Neighboring gene STARR-positive B cell enhancer ABC_E6936 Neighboring gene ubiquitin specific peptidase 15 Neighboring gene STARR-positive B cell enhancer ABC_E9134 Neighboring gene STARR-positive B cell enhancer ABC_E11464 Neighboring gene predicted gene, 36628 Neighboring gene predicted gene 4129

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development. Quesnel-Vallières M, et al. Genes Dev, 2015 Apr 1. PMID 25838543, Free PMC Article
    2. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
    4. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    5. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in Golgi to endosome transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein MON2 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163024.1 → NP_001156496.1  protein MON2 homolog isoform 1

      See identical proteins and their annotated locations for NP_001156496.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AA542162, AC153021, AC153911, AK081083, AK086647, BB614144, BE955337, CB244438, CF747261, CF747618, CN528444, CN702930, CV561694, CV563363, CX122556, CX224591
      Consensus CDS
      CCDS48707.1
      UniProtKB/Swiss-Prot
      Q3TRE3, Q80TL7, Q8BTA8, Q8K4V3
      Related
      ENSMUSP00000073462.4, ENSMUST00000073792.11
      Conserved Domains (4) summary
      pfam09324
      Location:870 → 929
      DUF1981; Domain of unknown function (DUF1981)
      pfam12783
      Location:211 → 378
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
      pfam16206
      Location:932 → 1706
      Mon2_C; C-terminal region of Mon2 protein
      pfam16213
      Location:9 → 183
      DCB; Dimerization and cyclophilin-binding domain of Mon2

    2. NM_001163025.1 → NP_001156497.1  protein MON2 homolog isoform 2

      See identical proteins and their annotated locations for NP_001156497.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site and lacks two in-frame exons in the coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
      Source sequence(s)
      AA542162, AC153021, AC153911, AK081083, AK086647, BB614144, BE955337, CB244438, CF747261, CF747618, CN525456, CN528444, CN702930, CV561694, CV563363, CX224591
      Consensus CDS
      CCDS48708.1
      UniProtKB/TrEMBL
      B9EKJ3
      Related
      ENSMUSP00000131052.2, ENSMUST00000170935.9
      Conserved Domains (4) summary
      pfam09324
      Location:870 → 929
      DUF1981; Domain of unknown function (DUF1981)
      pfam12783
      Location:211 → 380
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
      pfam16206
      Location:932 → 1700
      Mon2_C; C-terminal region of Mon2 protein
      pfam16213
      Location:9 → 183
      DCB; dimerization and cyclophilin-binding domain of Mon2

    3. NM_153395.2 → NP_700444.2  protein MON2 homolog isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two in-frame exons in the coding region compared to variant 1. This results in a shorter protein (isoform 3) compared to isoform 1.
      Source sequence(s)
      AA542162, AC153021, AC153911, AK081083, AK086647, BB614144, BE955337, CB244438, CF747261, CF747618, CN528444, CN702930, CV561694, CV563363, CX224591
      Consensus CDS
      CCDS24216.1
      UniProtKB/Swiss-Prot
      Q80TL7
      Related
      ENSMUSP00000037568.8, ENSMUST00000037557.9
      Conserved Domains (4) summary
      pfam09324
      Location:869 → 928
      DUF1981; Domain of unknown function (DUF1981)
      pfam12783
      Location:211 → 378
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
      pfam16206
      Location:931 → 1699
      Mon2_C; C-terminal region of Mon2 protein
      pfam16213
      Location:9 → 183
      DCB; Dimerization and cyclophilin-binding domain of Mon2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      122827965..122913684 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513969.5 → XP_006514032.1  protein MON2 homolog isoform X3

      Conserved Domains (4) summary
      pfam09324
      Location:869 → 928
      DUF1981; Domain of unknown function (DUF1981)
      pfam12783
      Location:211 → 378
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
      pfam16206
      Location:931 → 1705
      Mon2_C; C-terminal region of Mon2 protein
      pfam16213
      Location:9 → 180
      DCB; dimerization and cyclophilin-binding domain of Mon2

    2. XM_006513968.5 → XP_006514031.1  protein MON2 homolog isoform X2

      Conserved Domains (4) summary
      pfam09324
      Location:870 → 929
      DUF1981; Domain of unknown function (DUF1981)
      pfam12783
      Location:211 → 378
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
      pfam16206
      Location:932 → 1706
      Mon2_C; C-terminal region of Mon2 protein
      pfam16213
      Location:9 → 180
      DCB; dimerization and cyclophilin-binding domain of Mon2

    3. XM_006513970.5 → XP_006514033.1  protein MON2 homolog isoform X4

      Conserved Domains (4) summary
      pfam09324
      Location:871 → 930
      DUF1981; Domain of unknown function (DUF1981)
      pfam12783
      Location:211 → 378
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
      pfam16206
      Location:933 → 1701
      Mon2_C; C-terminal region of Mon2 protein
      pfam16213
      Location:9 → 180
      DCB; dimerization and cyclophilin-binding domain of Mon2

    4. XM_011243533.4 → XP_011241835.1  protein MON2 homolog isoform X1

      Conserved Domains (4) summary
      pfam09324
      Location:871 → 930
      DUF1981; Domain of unknown function (DUF1981)
      pfam12783
      Location:211 → 378
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
      pfam16206
      Location:933 → 1707
      Mon2_C; C-terminal region of Mon2 protein
      pfam16213
      Location:9 → 180
      DCB; dimerization and cyclophilin-binding domain of Mon2

    5. XM_017314065.3 → XP_017169554.1  protein MON2 homolog isoform X5

      Conserved Domains (4) summary
      pfam09324
      Location:799 → 858
      DUF1981; Domain of unknown function (DUF1981)
      pfam12783
      Location:139 → 306
      Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
      pfam16206
      Location:861 → 1635
      Mon2_C; C-terminal region of Mon2 protein
      pfam16213
      Location:1 → 108
      DCB; dimerization and cyclophilin-binding domain of Mon2

    6. XM_006513972.4 → XP_006514035.1  protein MON2 homolog isoform X6

      Conserved Domains (2) summary
      pfam09324
      Location:286 → 345
      DUF1981; Domain of unknown function (DUF1981)
      pfam16206
      Location:348 → 1122
      Mon2_C; C-terminal region of Mon2 protein

    RNA

    1. XR_380429.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80TL7.2 GenPept UniProtKB/Swiss-Prot:Q80TL7

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