WDR5a Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: WDR5a
Official Full Name: Transducin/WD40 repeat-like superfamily protein
Primary source: TAIR:AT3G49660
Locus tag: AT3G49660
See related: Araport:AT3G49660
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtWDR5a; human WDR5 (WD40 repeat) homolog a
Summary: Encodes a structural core component of a COMPASS-like H3K4 histone methylation complex.
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Genomic context

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See WDR5a in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 2

Sequence:: Chromosome: 3; NC_003074.8 (18413564..18415713)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WDR5a functions in cadmium-inhibited root meristem growth by regulating nitric oxide accumulation in Arabidopsis.
Title: WDR5a functions in cadmium-inhibited root meristem growth by regulating nitric oxide accumulation in Arabidopsis.
WDR5a role in controlling root meristem size in Arabidopsis.WDR5a affects auxin levels in roots by modulating the accumulation of nitric oxide.
Title: WD40-REPEAT 5a represses root meristem growth by suppressing auxin synthesis through changes of nitric oxide accumulation in Arabidopsis.
MAS activates MAF4 by interacting with WDR5a, one core component of the COMPASS-like complexes, and recruiting WDR5a to MAF4 to enhance histone 3 lysine 4 trimethylation (H3K4me3
Title: Global identification of Arabidopsis lncRNAs reveals the regulation of MAF4 by a natural antisense RNA.
WDR5a functions as a novel factor to modulate nitric oxide synthase-like activity for changes of nitric oxide accumulation and stomatal closure in drought stress tolerance.
Title: WD40-REPEAT 5a functions in drought stress tolerance by regulating nitric oxide accumulation in Arabidopsis.
bZIP28 and bZIP60 interact with Ash2 and WDR5a, both of which are core COMPASS-like components.
Title: Transcription factor interaction with COMPASS-like complex regulates histone H3K4 trimethylation for specific gene expression in plants.
WDR5a directly interacts with an H3K4 methyltransferase, ARABIDOPSIS TRITHORAX1.
Title: Establishment of the winter-annual growth habit via FRIGIDA-mediated histone methylation at FLOWERING LOCUS C in Arabidopsis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_114826.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables histone H3 methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within vegetative to reproductive phase transition of meristem	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Set1C/COMPASS complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Transducin/WD40 repeat-like superfamily protein

NP_190535.1

Transducin/WD40 repeat-like superfamily protein; FUNCTIONS IN: nucleotide binding; INVOLVED IN: G-protein coupled receptor protein signaling pathway; LOCATED IN: chloroplast, heterotrimeric G-protein complex; EXPRESSED IN: 6 plant structures; EXPRESSED DURING: F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Transducin/WD40 repeat-like superfamily protein (TAIR:AT4G02730.1); Has 118516 Blast hits to 43755 proteins in 1024 species: Archae - 92; Bacteria - 12360; Metazoa - 47439; Fungi - 25856; Plants - 15887; Viruses - 9; Other Eukaryotes - 16873 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

18413564..18415713

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_114826.4 → NP_190535.1 Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_190535.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9M2Z2

UniProtKB/TrEMBL

A0A178VK59, A0A5S9XK59

Conserved Domains (2) summary

cd00200
Location:16 → 312

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:27 → 69

7WD40; WD40 repeat [structural motif]