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    Eo Ecdysone oxidase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32423, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eoprovided by FlyBase
    Official Full Name
    Ecdysone oxidaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030597
    Locus tag
    Dmel_CG9504
    See related
    AllianceGenome:FB:FBgn0030597
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9504; Dmel\CG9504; DmEO; EO; EObeta1
    Summary
    Enables ecdysone oxidase activity. Involved in ecdysone metabolic process. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    13A1-13A1; 1-49 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (14916756..14918800, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14810789..14812833, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Flotillin 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cis-regulatory polymorphism at fiz ecdysone oxidase contributes to polygenic evolutionary response to malnutrition in Drosophila. Cavigliasso F, et al. PLoS Genet, 2024 Mar. PMID 38452112, Free PMC Article
    2. Selective sweep in the Flotillin-2 region of European Drosophila melanogaster. Werzner A, et al. PLoS One, 2013. PMID 23437190, Free PMC Article
    3. The steroid hormone ecdysone regulates growth rate in response to oxygen availability. Kapali GP, et al. Sci Rep, 2022 Mar 18. PMID 35304878, Free PMC Article
    4. Chronic exposure to the star polycation (SPc) nanocarrier in the larval stage adversely impairs life history traits in Drosophila melanogaster. Yan S, et al. J Nanobiotechnology, 2022 Dec 8. PMID 36482441, Free PMC Article
    5. Regulation of ecdysteroid signalling during Drosophila development: identification, characterization and modelling of ecdysone oxidase, an enzyme involved in control of ligand concentration. Takeuchi H, et al. Biochem J, 2005 Aug 1. PMID 15813704, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transcriptome profiling identifies multistep regulation through E93, Forkhead and Ecdysone Oxidase in survival of Malpighian tubules during metamorphosis in Drosophila.
      Title: Transcriptome profiling identifies multistep regulation through E93, Forkhead and Ecdysone Oxidase in survival of Malpighian tubules during metamorphosis in Drosophila.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ecdysone oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on CH-OH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ecdysone metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ecdysone oxidase
    Names
    CG9504-PA
    Eo-PA
    NP_572986.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      14916756..14918800 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132758.2 → NP_572986.1  ecdysone oxidase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572986.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VY01
      UniProtKB/TrEMBL
      M9WQ12, M9WVC9, M9WVR2
      Related
      FBpp0073792
      Conserved Domains (3) summary
      COG2303
      Location:88 → 649
      BetA; Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General function prediction only]
      pfam05199
      Location:490 → 638
      GMC_oxred_C; GMC oxidoreductase
      cl21454
      Location:185 → 375
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VY01.2 Q9VY01

    Gene LinkOut

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