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    H2AC21 H2A clustered histone 21 [ Homo sapiens (human) ]

    Gene ID: 317772, updated on 27-Nov-2024

    Summary

    Official Symbol
    H2AC21provided by HGNC
    Official Full Name
    H2A clustered histone 21provided by HGNC
    Primary source
    HGNC:HGNC:20508
    See related
    Ensembl:ENSG00000184270 MIM:615014; AllianceGenome:HGNC:20508
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    H2AB; HIST2H2AB
    Summary
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]
    Orthologs
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    Genomic context

    See H2AC21 in Genome Data Viewer
    Location:
    1q21.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (149887469..149887965, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (149011607..149012103, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (149859019..149859515, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1655 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:149856835-149857428 Neighboring gene H2B clustered histone 21 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1657 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1658 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1659 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1660 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1661 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1662 Neighboring gene H2A clustered histone 20 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:149859809-149860403 Neighboring gene uncharacterized LOC124904412 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1664 Neighboring gene bolA family member 1

    Genomic regions, transcripts, and products

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    part_of nucleosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    histone H2A type 2-B
    Names
    histone 2, H2ab
    histone cluster 2 H2A family member b
    histone cluster 2, H2ab

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175065.3NP_778235.1  histone H2A type 2-B

      See identical proteins and their annotated locations for NP_778235.1

      Status: REVIEWED

      Source sequence(s)
      AC239868
      Consensus CDS
      CCDS938.1
      UniProtKB/Swiss-Prot
      Q8IUE6
      UniProtKB/TrEMBL
      B2R5B3
      Related
      ENSP00000332790.4, ENST00000331128.6
      Conserved Domains (1) summary
      PTZ00017
      Location:1130
      PTZ00017; histone H2A; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      149887469..149887965 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      149011607..149012103 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)