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    PAGE2B PAGE family member 2B [ Homo sapiens (human) ]

    Gene ID: 389860, updated on 27-Nov-2024

    Summary

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    Official Symbol
    PAGE2Bprovided by HGNC
    Official Full Name
    PAGE family member 2Bprovided by HGNC
    Primary source
    HGNC:HGNC:31805
    See related
    Ensembl:ENSG00000238269 AllianceGenome:HGNC:31805
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT16.5; GAGEE3; PAGE-2B
    Expression
    Restricted expression toward testis (RPKM 8.7) See more
    Orthologs
    all
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    Genomic context

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    See PAGE2B in Genome Data Viewer
    Location:
    Xp11.21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (55028117..55078909)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (54321243..54372032)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (55101463..55105342)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chrX:54962395-54962556 Neighboring gene 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:54977103-54977603 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20865 Neighboring gene Sharpr-MPRA regulatory regions 2439 and 5762 Neighboring gene ALAS2 intronic erythroid enhancer Neighboring gene apurinic/apyrimidinic endodeoxyribonuclease 2 Neighboring gene ALAS2 intron 1 and 3 erythroid regulatory elements Neighboring gene 5'-aminolevulinate synthase 2 Neighboring gene HDGFL3 pseudogene 1 Neighboring gene PAGE family member 2 Neighboring gene CRISPRi-validated cis-regulatory element chrX.1184 Neighboring gene component of oligomeric golgi complex 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability. Achuthankutty D, et al. J Cell Biol, 2019 Dec 2. PMID 31615875, Free PMC Article
    2. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article
    3. Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674
    4. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    General protein information

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    Preferred Names
    putative G antigen family E member 3
    Names
    G antigen, family E, 3
    P antigen family, member 2B
    prostate-associated gene 2B protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015038.3 → NP_001015038.1  putative G antigen family E member 3

      See identical proteins and their annotated locations for NP_001015038.1

      Status: VALIDATED

      Source sequence(s)
      AL590240, BM782405, HY192793
      Consensus CDS
      CCDS35304.1
      UniProtKB/Swiss-Prot
      A1L414, Q5JRK9
      UniProtKB/TrEMBL
      Q5JRL0
      Related
      ENSP00000364110.1, ENST00000374971.2
      Conserved Domains (1) summary
      pfam05831
      Location:1 → 107
      GAGE; GAGE protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      55028117..55078909
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011530785.3 → XP_011529087.1  putative G antigen family E member 3 isoform X1

      See identical proteins and their annotated locations for XP_011529087.1

      Conserved Domains (1) summary
      pfam05831
      Location:24 → 133
      GAGE; GAGE protein

    2. XM_011530786.4 → XP_011529088.1  putative G antigen family E member 3 isoform X2

      See identical proteins and their annotated locations for XP_011529088.1

      UniProtKB/TrEMBL
      Q5JRL0
      Conserved Domains (1) summary
      pfam05831
      Location:6 → 115
      GAGE; GAGE protein

    3. XM_017029513.2 → XP_016885002.1  putative G antigen family E member 3 isoform X3

      UniProtKB/Swiss-Prot
      A1L414, Q5JRK9
      UniProtKB/TrEMBL
      Q5JRL0
      Conserved Domains (1) summary
      pfam05831
      Location:1 → 107
      GAGE; GAGE protein

    4. XM_011530787.3 → XP_011529089.1  putative G antigen family E member 3 isoform X3

      See identical proteins and their annotated locations for XP_011529089.1

      UniProtKB/Swiss-Prot
      A1L414, Q5JRK9
      UniProtKB/TrEMBL
      Q5JRL0
      Conserved Domains (1) summary
      pfam05831
      Location:1 → 107
      GAGE; GAGE protein

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      54321243..54372032
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327042.1 → XP_054183017.1  putative G antigen family E member 3 isoform X1

    2. XM_054327043.1 → XP_054183018.1  putative G antigen family E member 3 isoform X2

    3. XM_054327044.1 → XP_054183019.1  putative G antigen family E member 3 isoform X3

      UniProtKB/Swiss-Prot
      A1L414, Q5JRK9

    4. XM_054327045.1 → XP_054183020.1  putative G antigen family E member 3 isoform X3

      UniProtKB/Swiss-Prot
      A1L414, Q5JRK9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5JRK9.1 GenPept UniProtKB/Swiss-Prot:Q5JRK9

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