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    Msr1 macrophage scavenger receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 20288, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Msr1provided by MGI
    Official Full Name
    macrophage scavenger receptor 1provided by MGI
    Primary source
    MGI:MGI:98257
    See related
    Ensembl:ENSMUSG00000025044 AllianceGenome:MGI:98257
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MSR; SR-A; Scvr; MRS-A; MSR-A; SR-AI; SR-AII; Scara1
    Summary
    Enables amyloid-beta binding activity; cargo receptor activity; and low-density lipoprotein particle binding activity. Involved in several processes, including endocytosis; positive regulation of cholesterol storage; and positive regulation of macrophage derived foam cell differentiation. Acts upstream of or within establishment of localization in cell and lipoprotein transport. Located in plasma membrane. Is expressed in several structures, including alimentary system; early conceptus; limb; neural tube; and reproductive system. Human ortholog(s) of this gene implicated in Barrett's esophagus; arteriosclerosis; and prostate cancer. Orthologous to human MSR1 (macrophage scavenger receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver E18 (RPKM 1.9), liver E14 (RPKM 1.1) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Msr1 in Genome Data Viewer
    Location:
    8 A4; 8 23.89 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (39996284..40095790, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (39543232..39642750, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21254 Neighboring gene predicted gene 6213 Neighboring gene voltage-dependent anion channel 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_21255 Neighboring gene STARR-seq mESC enhancer starr_21257 Neighboring gene copine VIII pseudogene Neighboring gene STARR-seq mESC enhancer starr_21258 Neighboring gene H/ACA ribonucleoprotein complex subunit 3 pseudogene Neighboring gene predicted gene, 36741

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SR-A regulates the inflammatory activation of astrocytes. Murgas P, et al. Neurotox Res, 2014 Jan. PMID 24114771
    2. Scavenger receptor A deficiency accelerates cerebrovascular amyloidosis in an animal model. Lifshitz V, et al. J Mol Neurosci, 2013 May. PMID 23108486
    3. SR-A deficiency reduces myocardial ischemia/reperfusion injury; involvement of increased microRNA-125b expression in macrophages. Ren D, et al. Biochim Biophys Acta, 2013 Feb. PMID 23123599, Free PMC Article
    4. Identification and characterization of naturally occurring variants of the macrophage scavenger receptor (SR-A). Fortin A, et al. Mamm Genome, 2000 Sep. PMID 10967138
    5. Delayed growth of EL4 lymphoma in SR-A-deficient mice is due to upregulation of nitric oxide and interferon-gamma production by tumor-associated macrophages. Komohara Y, et al. Cancer Sci, 2009 Nov. PMID 19694752, Free PMC Article

    See all (267) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Macrophage scavenger receptor A1 antagonizes abdominal aortic aneurysm via upregulating IRG1.
      Title: Macrophage scavenger receptor A1 antagonizes abdominal aortic aneurysm via upregulating IRG1.
    2. MSR1 is not required for obesity-associated inflammation and insulin resistance in mice.
      Title: MSR1 is not required for obesity-associated inflammation and insulin resistance in mice.
    3. Role of macrophage scavenger receptor MSR1 in the progression of non-alcoholic steatohepatitis.
      Title: Role of macrophage scavenger receptor MSR1 in the progression of non-alcoholic steatohepatitis.
    4. SRA Suppresses Antiviral Innate Immune Response in Macrophages by Limiting TBK1 K63 Ubiquitination via Deubiquitinase USP15.
      Title: SRA Suppresses Antiviral Innate Immune Response in Macrophages by Limiting TBK1 K63 Ubiquitination via Deubiquitinase USP15.
    5. Blocking Msr1 by berberine alkaloids inhibits caspase-11-dependent coagulation in bacterial sepsis.
      Title: Blocking Msr1 by berberine alkaloids inhibits caspase-11-dependent coagulation in bacterial sepsis.
    6. The CD36 and SR-A/CD204 scavenger receptors fine-tune Staphylococcus aureus-stimulated cytokine production in mouse macrophages.
      Title: The CD36 and SR-A/CD204 scavenger receptors fine-tune Staphylococcus aureus-stimulated cytokine production in mouse macrophages.
    7. The role of macrophage scavenger receptor 1 (Msr1) in prion pathogenesis.
      Title: The role of macrophage scavenger receptor 1 (Msr1) in prion pathogenesis.
    8. Critical contribution of macrophage scavenger receptor 1 to the uptake of nanostructured DNA by immune cells.
      Title: Critical contribution of macrophage scavenger receptor 1 to the uptake of nanostructured DNA by immune cells.
    9. Scavenger receptor A1 participates in uptake of Leptospira interrogans serovar Autumnalis strain 56606v and inflammation in mouse macrophages.
      Title: Scavenger receptor A1 participates in uptake of Leptospira interrogans serovar Autumnalis strain 56606v and inflammation in mouse macrophages.
    10. Glycoursodeoxycholic Acid Ameliorates Atherosclerosis and Alters Gut Microbiota in Apolipoprotein E-Deficient Mice.
      Title: Glycoursodeoxycholic Acid Ameliorates Atherosclerosis and Alters Gut Microbiota in Apolipoprotein E-Deficient Mice.
    Submit: New GeneRIF Correction See all GeneRIFs (126)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables amyloid-beta binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amyloid-beta binding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables cargo receptor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables low-density lipoprotein particle binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables low-density lipoprotein particle binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables scavenger receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amyloid-beta clearance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amyloid-beta clearance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in amyloid-beta clearance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cholesterol transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lipoprotein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phagocytosis, engulfment IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in plasma lipoprotein particle clearance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in plasma lipoprotein particle clearance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cholesterol storage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cholesterol storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of macrophage derived foam cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in receptor-mediated endocytosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of low-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    macrophage scavenger receptor types I and II
    Names
    macrophage acetylated LDL receptor I and II
    scavenger receptor type A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113326.2 → NP_001106797.2  macrophage scavenger receptor types I and II isoform b

      Status: VALIDATED

      Source sequence(s)
      AC111028
      Consensus CDS
      CCDS52542.1
      Related
      ENSMUSP00000026021.7, ENSMUST00000026021.14

    2. NM_031195.3 → NP_112472.3  macrophage scavenger receptor types I and II isoform a

      Status: VALIDATED

      Source sequence(s)
      AC111028
      Consensus CDS
      CCDS52543.1
      Related
      ENSMUSP00000132535.2, ENSMUST00000170091.3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      39996284..40095790 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509311.4 → XP_006509374.1  macrophage scavenger receptor types I and II isoform X1

      UniProtKB/Swiss-Prot
      E9QNQ5, P30204, Q923G0, Q9QZ56
      Conserved Domains (4) summary
      pfam01391
      Location:306 → 367
      Collagen; Collagen triple helix repeat (20 copies)
      smart00202
      Location:386 → 443
      SR; Scavenger receptor Cys-rich
      COG0840
      Location:147 → 304
      Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
      pfam03523
      Location:154 → 202
      Macscav_rec; Macrophage scavenger receptor

    2. XM_006509312.4 → XP_006509375.1  macrophage scavenger receptor types I and II isoform X2

      UniProtKB/Swiss-Prot
      E9QNQ5, P30204, Q923G0, Q9QZ56
      Conserved Domains (4) summary
      pfam01391
      Location:273 → 334
      Collagen; Collagen triple helix repeat (20 copies)
      smart00202
      Location:353 → 453
      SR; Scavenger receptor Cys-rich
      COG0840
      Location:114 → 271
      Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
      pfam03523
      Location:121 → 169
      Macscav_rec; Macrophage scavenger receptor
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30204.3 GenPept UniProtKB/Swiss-Prot:P30204

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