Exoc6 exocyst complex component 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Exoc6provided by MGI
Official Full Name: exocyst complex component 6provided by MGI
Primary source: MGI:MGI:1351611
See related: Ensembl:ENSMUSG00000053799 AllianceGenome:MGI:1351611
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: hbd; Sec15; msec15; Sec15l1; C430002C19; 4833405E05Rik
Summary: Acts upstream of or within erythrocyte differentiation. Predicted to be located in plasma membrane. Predicted to be part of exocyst. Is expressed in central nervous system; dorsal root ganglion; foregut; genitourinary system; and liver lobe. Orthologous to human EXOC6 (exocyst complex component 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 12.6), liver E14 (RPKM 11.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C2; 19 32.32 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (37525181..37672499)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (37536763..37684052)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that the association of Rab10-GTP with Exoc6/6b is a molecular link between insulin signaling and the exocytic machinery in GLUT4 translocation.
Title: A potential link between insulin signaling and GLUT4 translocation: Association of Rab10-GTP with the exocyst subunit Exoc6/6b.
Exoc3l is involved in regulated exocytosis of insulin granules; expressed in insulin-secreting cells as well as in various tissues including pancreatic islets and brain.
Title: Involvement of Exoc3l, a protein structurally related to the exocyst subunit Sec6, in insulin secretion.
These data indicate that rapid transferrin recycling is defective after pSec15l1 has mutated.
Title: Loss of rapid transferrin receptor recycling due to a mutation in Sec15l1 in hbd mice.
Iron metabolism mutant hbd mice have an exon deletion in Sec15l1.
Title: Iron metabolism mutant hbd mice have a deletion in Sec15l1, which has homology to a yeast gene for vesicle docking.
Mutation in Sec15l1 causes anemia in hemoglobin deficit mice.
Title: A mutation in Sec15l1 causes anemia in hemoglobin deficit (hbd) mice.

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Phenotypes

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Associated conditions

Description	Tests
hemoglobin deficient GeneReviews: Not available

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Spontaneous (1) 1 citation
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D19Mit101 (e-PCR), detects polymorphism
- UniSTS:128316

D19Dcr28 (e-PCR), detects polymorphism
- UniSTS:532348

AW413330 (e-PCR)
- UniSTS:181231

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in membrane fission	NAS Non-traceable Author Statement more info	PubMed
involved_in mitotic cytokinesis	NAS Non-traceable Author Statement more info	PubMed
involved_in vesicle docking involved in exocytosis	NAS Non-traceable Author Statement more info	PubMed
involved_in vesicle tethering involved in exocytosis	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in Flemming body	IEA Inferred from Electronic Annotation more info
part_of exocyst	IBA Inferred from Biological aspect of Ancestor more info
part_of exocyst	NAS Non-traceable Author Statement more info	PubMed
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: exocyst complex component 6

Names: SEC15 homolog; SEC15-like 1; SEC15-like protein 1; exocyst complex component Sec15A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175353.2 → NP_780562.2 exocyst complex component 6

See identical proteins and their annotated locations for NP_780562.2

Status: VALIDATED

Source sequence(s)

AC110212, AK076455, AK082881, BY100185, CD806857

Consensus CDS

CCDS29779.1

UniProtKB/TrEMBL

A0A5F8MPW8, Q3U9D6

Related

ENSMUSP00000064332.7, ENSMUST00000066439.8

Conserved Domains (1) summary

pfam04091
Location:456 → 762

Sec15; Exocyst complex subunit Sec15-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

37525181..37672499

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017318044.2 → XP_017173533.1 exocyst complex component 6 isoform X1

UniProtKB/TrEMBL

A0A5F8MP92, A0A5F8MPW8

Related

ENSMUSP00000158866.2, ENSMUST00000238954.2

Conserved Domains (1) summary

pfam04091
Location:463 → 769

Sec15; Exocyst complex subunit Sec15-like