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    Tfb2m transcription factor B2, mitochondrial [ Mus musculus (house mouse) ]

    Gene ID: 15278, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tfb2mprovided by MGI
    Official Full Name
    transcription factor B2, mitochondrialprovided by MGI
    Primary source
    MGI:MGI:107937
    See related
    Ensembl:ENSMUSG00000026492 AllianceGenome:MGI:107937
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hkp1; mTFB2M; mtTFB2
    Summary
    Predicted to enable mitochondrial transcription factor activity and rRNA (adenine-N6,N6-)-dimethyltransferase activity. Predicted to be involved in rRNA methylation and transcription initiation at mitochondrial promoter. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and integumental system. Orthologous to human TFB2M (transcription factor B2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 8.1), heart adult (RPKM 6.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Tfb2m in Genome Data Viewer
    Location:
    1 H4; 1 83.56 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (179355617..179373870, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (179528052..179546305, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene SET and MYND domain containing 3 Neighboring gene predicted gene, 31349 Neighboring gene STARR-seq mESC enhancer starr_03170 Neighboring gene STARR-seq mESC enhancer starr_03171 Neighboring gene STARR-seq mESC enhancer starr_03172 Neighboring gene STARR-positive B cell enhancer ABC_E10067 Neighboring gene STARR-positive B cell enhancer ABC_E3339 Neighboring gene STARR-positive B cell enhancer mm9_chr1:181437064-181437364 Neighboring gene STARR-positive B cell enhancer mm9_chr1:181447992-181448293 Neighboring gene STARR-positive B cell enhancer ABC_E2590 Neighboring gene STARR-positive B cell enhancer ABC_E4399 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:181508880-181509063 Neighboring gene ribosomal protein L29 pseudogene Neighboring gene consortin, connexin sorting protein Neighboring gene STARR-seq mESC enhancer starr_03181 Neighboring gene saccharopine dehydrogenase (putative)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mitochondrial transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mitochondrial transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables rRNA (adenine-N6,N6-)-dimethyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables rRNA (adenine-N6,N6-)-dimethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in rRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in rRNA methylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcription initiation at mitochondrial promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in transcription initiation at mitochondrial promoter ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transcription initiation at mitochondrial promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial nucleoid IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dimethyladenosine transferase 2, mitochondrial
    Names
    S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2
    house-keeping protein 1
    mitochondrial 12S rRNA dimethylase 2
    mitochondrial transcription factor B2
    NP_001317983.1
    NP_001317984.1
    NP_001407149.1
    NP_001407150.1
    NP_001407151.1
    NP_001407152.1
    NP_001407153.1
    NP_032275.2
    XP_006496729.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001331054.2NP_001317983.1  dimethyladenosine transferase 2, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC130279
      Conserved Domains (1) summary
      cl17173
      Location:81356
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. NM_001331055.2NP_001317984.1  dimethyladenosine transferase 2, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC130279
      UniProtKB/Swiss-Prot
      Q3TL26
      Conserved Domains (1) summary
      cl17173
      Location:48239
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    3. NM_001420220.1NP_001407149.1  dimethyladenosine transferase 2, mitochondrial isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC130279
    4. NM_001420221.1NP_001407150.1  dimethyladenosine transferase 2, mitochondrial isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC130279
    5. NM_001420222.1NP_001407151.1  dimethyladenosine transferase 2, mitochondrial isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC130279
    6. NM_001420223.1NP_001407152.1  dimethyladenosine transferase 2, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC130279
    7. NM_001420224.1NP_001407153.1  dimethyladenosine transferase 2, mitochondrial isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC130279
    8. NM_008249.6NP_032275.2  dimethyladenosine transferase 2, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_032275.2

      Status: VALIDATED

      Source sequence(s)
      AC130279
      Consensus CDS
      CCDS15561.1
      UniProtKB/Swiss-Prot
      Q3TL26, Q61669, Q8BTJ2
      UniProtKB/TrEMBL
      B2RSE6
      Related
      ENSMUSP00000027769.6, ENSMUST00000027769.6
      Conserved Domains (1) summary
      cl17173
      Location:81377
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      179355617..179373870 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496666.3XP_006496729.1  dimethyladenosine transferase 2, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006496729.1

      Conserved Domains (1) summary
      cl17173
      Location:48239
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RNA

    1. XR_001781680.1 RNA Sequence

    2. XR_004940118.1 RNA Sequence