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    DREB2A DRE-binding protein 2A [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830424, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DREB2A
    Official Full Name
    DRE-binding protein 2A
    Primary source
    TAIR:AT5G05410
    Locus tag
    AT5G05410
    See related
    Araport:AT5G05410
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    DEHYDRATION-RESPONSIVE ELEMENT BINDING PROTEIN 2; DRE-binding protein 2A; DREB2; K18I23.22; K18I23_22
    Summary
    Encodes a transcription factor that specifically binds to DRE/CRT cis elements (responsive to drought and low-temperature stress). Belongs to the DREB subfamily A-2 of ERF/AP2 transcription factor family (DREB2A). There are eight members in this subfamily including DREB2B. The protein contains one AP2 domain. Overexpression of transcriptional activation domain of DREB2A resulted in significant drought stress tolerance but only slight freezing tolerance in transgenic Arabidopsis plants. Microarray and RNA gel blot analyses revealed that DREB2A regulates expression of many water stress#Aeiinducible genes.
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    Genomic context

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    See DREB2A in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    2
    Sequence:
    Chromosome: 5; NC_003076.8 (1602205..1604112)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene laccase 12 Neighboring gene LRR and NB-ARC domains-containing disease resistance protein Neighboring gene FKBP-like peptidyl-prolyl cis-trans isomerase family protein Neighboring gene RNA-binding protein Neighboring gene ncRNA Neighboring gene Polyketide cyclase/dehydrase and lipid transport superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An ABRE promoter sequence is involved in osmotic stress-responsive expression of the DREB2A gene, which encodes a transcription factor regulating drought-inducible genes in Arabidopsis. Kim JS, et al. Plant Cell Physiol, 2011 Dec. PMID 22025559
    2. Heat-induced inhibition of phosphorylation of the stress-protective transcription factor DREB2A promotes thermotolerance of Arabidopsis thaliana. Mizoi J, et al. J Biol Chem, 2019 Jan 18. PMID 30487287, Free PMC Article
    3. Stabilization of Arabidopsis DREB2A is required but not sufficient for the induction of target genes under conditions of stress. Morimoto K, et al. PLoS One, 2013. PMID 24376497, Free PMC Article
    4. BPM-CUL3 E3 ligase modulates thermotolerance by facilitating negative regulatory domain-mediated degradation of DREB2A in Arabidopsis. Morimoto K, et al. Proc Natl Acad Sci U S A, 2017 Oct 3. PMID 28923951, Free PMC Article
    5. Induced over-expression of AtDREB2A CA improves drought tolerance in sugarcane. Reis RR, et al. Plant Sci, 2014 May. PMID 24656336

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These observations suggest that inhibition of NRD phosphorylation stabilizes and activates DREB2A in response to heat stress to enhance plant thermotolerance.
      Title: Heat-induced inhibition of phosphorylation of the stress-protective transcription factor DREB2A promotes thermotolerance of Arabidopsis thaliana.
    2. Genetic analysis indicated that the depletion of BTB/POZ AND MATH DOMAIN protein expression conferred enhanced thermotolerance via DREB2A stabilization
      Title: BPM-CUL3 E3 ligase modulates thermotolerance by facilitating negative regulatory domain-mediated degradation of DREB2A in Arabidopsis.
    3. NMR spectroscopy further demonstrated that DREB2A underwent coupled folding and binding with alpha-helix formation upon interaction with RCD1, whereas peptides from ANAC013 and ANAC046 formed different structures or were fuzzy in the complexes.
      Title: Structures and Short Linear Motif of Disordered Transcription Factor Regions Provide Clues to the Interactome of the Cellular Hub Protein Radical-induced Cell Death1.
    4. DPB3-1 associates with NF-YA and NF-YB subunits to enhance heat stress-inducible gene expression during heat stress responses in cooperation with DREB2A.
      Title: Arabidopsis DPB3-1, a DREB2A interactor, specifically enhances heat stress-induced gene expression by forming a heat stress-specific transcriptional complex with NF-Y subunits.
    5. transcriptional responses of the OPDA-responsive genes HsfA2 and DREB2A to the protein synthesis inhibitor cycloheximide and to the HSP90 inhibitor geldanamycin
      Title: Mechanisms of induction of the stress-responsive transcription factors HsfA2 and DREB2A by 12-oxo-phytodienoic acid in Arabidopsis thaliana.
    6. In this study, an attempt has been made to improve CT in drought hardy crop, peanut (Arachis hypogaea L., cv. TMV2) by co-expressing stress-responsive transcription factors (TFs), AtDREB2A, AtHB7 and AtABF3, associated with downstream gene expression
      Title: Simultaneous expression of abiotic stress responsive transcription factors, AtDREB2A, AtHB7 and AtABF3 improves salinity and drought tolerance in peanut (Arachis hypogaea L.).
    7. The stabilization of DREB2A is important but not sufficient to induce target gene expression; further activation processes are required.
      Title: Stabilization of Arabidopsis DREB2A is required but not sufficient for the induction of target genes under conditions of stress.
    8. The stress-inducible expression of Arabidopsis thaliana DREB2A CA in transgenic sugarcane led to the up-regulation of genes involved in plant response to drought stress.
      Title: Induced over-expression of AtDREB2A CA improves drought tolerance in sugarcane.
    9. GRF7 binds to a region of the DREB2A promoter and represses its activity.
      Title: Arabidopsis growth-regulating factor7 functions as a transcriptional repressor of abscisic acid- and osmotic stress-responsive genes, including DREB2A.
    10. Functional interactions between Dreb2a and Med25 induce conformational changes which in turn cause changes in their binding affinity.
      Title: Interactions between DNA, transcriptional regulator Dreb2a and the Med25 mediator subunit from Arabidopsis thaliana involve conformational changes.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001036760.1
    NM_120623.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to hypoxia HEP PubMed 
    acts_upstream_of_or_within heat acclimation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to UV-B IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to UV-B IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to heat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to hydrogen peroxide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    DRE-binding protein 2A
    NP_001031837.1
    • DRE-binding protein 2A (DREB2A); CONTAINS InterPro DOMAIN/s: DNA-binding, integrase-type (InterPro:IPR016177), Pathogenesis-related transcriptional factor/ERF, DNA-binding (InterPro:IPR001471); BEST Arabidopsis thaliana protein match is: DRE/CRT-binding protein 2B (TAIR:AT3G11020.1); Has 5407 Blast hits to 5383 proteins in 247 species: Archae - 0; Bacteria - 2; Metazoa - 0; Fungi - 0; Plants - 5390; Viruses - 4; Other Eukaryotes - 11 (source: NCBI BLink).
    NP_196160.1
    • DRE-binding protein 2A (DREB2A); CONTAINS InterPro DOMAIN/s: DNA-binding, integrase-type (InterPro:IPR016177), Pathogenesis-related transcriptional factor/ERF, DNA-binding (InterPro:IPR001471); BEST Arabidopsis thaliana protein match is: DRE/CRT-binding protein 2B (TAIR:AT3G11020.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      1602205..1604112
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120623.3 → NP_196160.1  DRE-binding protein 2A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196160.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82132, Q5Y4C5
      UniProtKB/TrEMBL
      A0A5S9Y271, A0A7G2FAJ0
      Conserved Domains (1) summary
      smart00380
      Location:78 → 141
      AP2; DNA-binding domain in plant proteins such as APETALA2 and EREBPs

    2. NM_001036760.1 → NP_001031837.1  DRE-binding protein 2A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031837.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9Y271, A8MSB1
      Conserved Domains (1) summary
      smart00380
      Location:78 → 141
      AP2; DNA-binding domain in plant proteins such as APETALA2 and EREBPs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O82132.1

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