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    NHX8 Na+/H+ exchanger 8 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838028, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NHX8
    Official Full Name
    Na+/H+ exchanger 8
    Primary source
    TAIR:AT1G14660
    Locus tag
    AT1G14660
    See related
    Araport:AT1G14660
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATNHX8; F10B6.1; F10B6_1; Na+/H+ exchanger 8; SODIUM HYDROGEN EXCHANGER 8
    Summary
    member of putative Na+/H+ antiporter (AtNHX) family. Functions as a plasma membrane Li+/H+ antiporter. Involved in Li+ efflux and detoxification.
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    Genomic context

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    See NHX8 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    19
    Sequence:
    Chromosome: 1; NC_003070.9 (5031943..5036610, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene SWAP (Suppressor-of-White-APricot)/surp domain-containing protein / ubiquitin family protein Neighboring gene ncRNA Neighboring gene Endomembrane protein 70 protein family Neighboring gene early endosome antigen

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AtNHX8, a member of the monovalent cation: proton antiporter-1 family in Arabidopsis thaliana, encodes a putative Li/H antiporter. An R, et al. Plant J, 2007 Feb. PMID 17270011
    2. Uncovering Arabidopsis membrane protein interactome enriched in transporters using mating-based split ubiquitin assays and classification models. Chen J, et al. Front Plant Sci, 2012. PMID 22737156, Free PMC Article
    3. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001198066.1
    NM_101333.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables lithium:proton antiporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    NOT enables sodium ion transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables sodium:proton antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium:proton antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lithium ion export across the plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lithium ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in sodium ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Na+/H+ exchanger 8
    NP_001184995.1
    • Na+/H+ exchanger 8 (NHX8); CONTAINS InterPro DOMAIN/s: Cation/H+ exchanger, conserved region (InterPro:IPR018422), Cation/H+ exchanger (InterPro:IPR006153), Na+/H+ exchanger, isoforms 7/8, conserved region (InterPro:IPR018418); BEST Arabidopsis thaliana protein match is: sodium proton exchanger, putative (NHX7) (SOS1) (TAIR:AT2G01980.1).
    NP_172918.2
    • Na+/H+ exchanger 8 (NHX8); CONTAINS InterPro DOMAIN/s: Cation/H+ exchanger, conserved region (InterPro:IPR018422), Cation/H+ exchanger (InterPro:IPR006153), Na+/H+ exchanger, isoforms 7/8, conserved region (InterPro:IPR018418); BEST Arabidopsis thaliana protein match is: sodium proton exchanger, putative (NHX7) (SOS1) (TAIR:AT2G01980.1); Has 7911 Blast hits to 7887 proteins in 1969 species: Archae - 132; Bacteria - 5569; Metazoa - 988; Fungi - 148; Plants - 408; Viruses - 0; Other Eukaryotes - 666 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      5031943..5036610 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101333.5 → NP_172918.2  Na+/H+ exchanger 8 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172918.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3YL57, Q9LQW7, Q9MA19
      UniProtKB/TrEMBL
      A0A5S9UGZ1, A0A7G2DQR3
      Conserved Domains (1) summary
      COG0025
      Location:30 → 463
      NhaP; NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism]

    2. NM_001198066.1 → NP_001184995.1  Na+/H+ exchanger 8 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001184995.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2DUR4, F4HW96
      Conserved Domains (2) summary
      TIGR00831
      Location:56 → 544
      a_cpa1; Na+/H+ antiporter, bacterial form
      COG0025
      Location:30 → 440
      NhaP; NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3YL57.1

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