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    Teh2 tipE homolog 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38502, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Teh2provided by FlyBase
    Official Full Name
    tipE homolog 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0035505
    Locus tag
    Dmel_CG15004
    See related
    AllianceGenome:FB:FBgn0035505
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15004; Dmel\CG15004; TEH1; TEH2
    Summary
    Enables sodium channel regulator activity. Involved in regulation of sodium ion transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in central brain primordium; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Teh2 in Genome Data Viewer
    Location:
    64A9-64A10; 3-10 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4178980..4188023, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4178980..4188023, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Endoplasmic reticulum oxidoreductin-1-like Neighboring gene uncharacterized protein Neighboring gene tipE homolog 4 Neighboring gene Vacuolar H[+] ATPase M9.7 subunit c Neighboring gene tipE homolog 3 Neighboring gene temperature-induced paralytic E Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Distinct modulating effects of TipE-homologs 2-4 on Drosophila sodium channel splice variants. Wang L, et al. Insect Biochem Mol Biol, 2015 May. PMID 25744892
    2. Alcohol-Induced Neuroadaptation Is Orchestrated by the Histone Acetyltransferase CBP. Ghezzi A, et al. Front Mol Neurosci, 2017. PMID 28442993, Free PMC Article
    3. A remarkably stable TipE gene cluster: evolution of insect Para sodium channel auxiliary subunits. Li J, et al. BMC Evol Biol, 2011 Nov 18. PMID 22098672, Free PMC Article
    4. Four novel sequences in Drosophila melanogaster homologous to the auxiliary Para sodium channel subunit TipE. Derst C, et al. Biochem Biophys Res Commun, 2006 Jan 20. PMID 16325765
    5. Alcohol-induced histone acetylation reveals a gene network involved in alcohol tolerance. Ghezzi A, et al. PLoS Genet, 2013. PMID 24348266, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. increased the amplitude of peak current, but did not alter the gating properties of three DmNav splice variants
      Title: Distinct modulating effects of TipE-homologs 2-4 on Drosophila sodium channel splice variants.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables sodium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium channel regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of sodium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of sodium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tipE homolog 2
    Names
    CG15004-PA
    CG15004-PB
    Teh2-PA
    Teh2-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4178980..4188023 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139610.4 → NP_647867.1  tipE homolog 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647867.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DNE8, Q9VZG9
      Related
      FBpp0073114
      Conserved Domains (1) summary
      pfam16972
      Location:73 → 271
      TipE; Na+ channel auxiliary subunit TipE

    2. NM_001169874.3 → NP_001163345.1  tipE homolog 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163345.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DNE8, B6IDT8
      Conserved Domains (1) summary
      pfam16972
      Location:73 → 271
      TipE; Na+ channel auxiliary subunit TipE
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B6IDT8 B6IDT8
    Q9VZG9 Q9VZG9

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