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    CG17746 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38400, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG17746provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035425
    Locus tag
    Dmel_CG17746
    See related
    AllianceGenome:FB:FBgn0035425
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Cg17746; Dmel\CG17746; PP2C
    Summary
    Predicted to enable phosphoprotein phosphatase activity. Predicted to be involved in signal transduction. Predicted to be located in cytosol. Is expressed in adult head and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG17746 in Genome Data Viewer
    Location:
    63C1-63C1; 3-7 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3236805..3239578, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3236805..3239578, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 1 Neighboring gene La-related protein 4B Neighboring gene long non-coding RNA:CR45424 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A phosphoswitch at acinus-serine(437) controls autophagic responses to cadmium exposure and neurodegenerative stress. Nandi N, et al. Elife, 2022 Jan 17. PMID 35037620, Free PMC Article
    2. Drak/STK17A Drives Neoplastic Glial Proliferation through Modulation of MRLC Signaling. Chen AS, et al. Cancer Res, 2019 Mar 15. PMID 30530503, Free PMC Article
    3. An RNAi Screen To Identify Protein Phosphatases That Function Within the Drosophila Circadian Clock. Agrawal P, et al. G3 (Bethesda), 2016 Dec 7. PMID 27784754, Free PMC Article
    4. Viability, longevity, and egg production of Drosophila melanogaster are regulated by the miR-282 microRNA. Vilmos P, et al. Genetics, 2013 Oct. PMID 23852386, Free PMC Article
    5. Cell competition removes segmental aneuploid cells from Drosophila imaginal disc-derived tissues based on ribosomal protein gene dose. Ji Z, et al. Elife, 2021 Apr 13. PMID 33847264, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cation binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG17746-PA
    CG17746-PB
    protein phosphatase 2C
    NP_647794.1
    NP_728844.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3236805..3239578 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168008.3 → NP_728844.1  uncharacterized protein Dmel_CG17746, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728844.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZS1
      Related
      FBpp0072956
      Conserved Domains (1) summary
      cd00143
      Location:22 → 284
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

    2. NM_139537.4 → NP_647794.1  uncharacterized protein Dmel_CG17746, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647794.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZS1
      Related
      FBpp0072955
      Conserved Domains (1) summary
      cd00143
      Location:22 → 284
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VZS1 Q9VZS1

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