plr-1 putative E3 ubiquitin-protein ligase plr-1 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: plr-1
Official Full Name: putative E3 ubiquitin-protein ligase plr-1
Primary source: WormBase:WBGene00023404
Locus tag: CELE_Y47D3B.11
See related: AllianceGenome:WB:WBGene00023404
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ubiquitin-protein transferase activity. Involved in negative regulation of Wnt signaling pathway. Located in Golgi apparatus; early endosome; and late endosome. Is expressed in several structures, including enteric muscle; excretory cell; neurons; pharynx; and tail. Human ortholog(s) of this gene implicated in endometrial cancer; gastrointestinal system cancer (multiple); irritable bowel syndrome; lung adenocarcinoma; and villous adenoma. Orthologous to human RNF43 (ring finger protein 43) and ZNRF3 (zinc and ring finger 3). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

PLR-1 is a putative E3 ubiquitin ligase that controls cell polarity and axonal extensions in C. elegans
Title: PLR-1, a putative E3 ubiquitin ligase, controls cell polarity and axonal extensions in C. elegans.
In a Frizzled-dependent manner, PLR-1 reduces surface levels of the Wnt receptors CAM-1/Ror and LIN-18/Ryk.
Title: The conserved transmembrane RING finger protein PLR-1 downregulates Wnt signaling by reducing Frizzled, Ror and Ryk cell-surface levels in C. elegans.

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome	IEA Inferred from Electronic Annotation more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

NP_499473.2

NEW Try the new Transcript table

The following sections contain reference sequences that belong to a specific genome build. Explain