zmp-2 Matrix metalloproteinase-B [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: zmp-2
Official Full Name: Matrix metalloproteinase-B
Primary source: WormBase:WBGene00019212
Locus tag: CELE_H19M22.3
See related: AllianceGenome:WB:WBGene00019212
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables metallopeptidase activity. Involved in several processes, including determination of adult lifespan; ecdysis, collagen and cuticulin-based cuticle; and negative regulation of protein import into nucleus. Predicted to be located in extracellular matrix and extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including RME; anal region; gonad; tail; and vulval muscle. Orthologous to human MMP23B (matrix metallopeptidase 23B). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See zmp-2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 9

Sequence:: Chromosome: III; NC_003281.10 (2636383..2642864)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A pleiotropic MMP gene regulating disease resistance, molting, larval development, and fecundity in C. elegans.
Title: Role of matrix metalloproteinase ZMP-2 in pathogen resistance and development in Caenorhabditis elegans.

Submit: New GeneRIF Correction

General gene information

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Markers

H19M22.3 (e-PCR)
- UniSTS:311332

STS3-121 (e-PCR)
- UniSTS:241960

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in collagen catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ecdysis, collagen and cuticulin-based cuticle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in heat acclimation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in heat acclimation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein oxidation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of protein oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of reactive oxygen species biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of reactive oxygen species biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cellular response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cholesterol import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of eating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Matrix metalloproteinase-B

NP_001360085.1

Confirmed by transcript evidence

NP_497594.1

Confirmed by transcript evidence

NP_497596.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

2636383..2642864

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001373860.1 → NP_001360085.1 Matrix metalloproteinase-B [Caenorhabditis elegans]

Status: REVIEWED
NM_065193.6 → NP_497594.1 Matrix metalloproteinase-B [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497594.1

Status: REVIEWED

UniProtKB/Swiss-Prot

H2L0C2, O44836, O61265, Q95X57

Conserved Domains (1) summary

cd04278
Location:134 → 321

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
NM_065195.5 → NP_497596.2 Matrix metalloproteinase-B [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497596.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O44836

Conserved Domains (2) summary

cd04278
Location:102 → 289

ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...

pfam00413
Location:102 → 289

Peptidase_M10; Matrixin