inf-1 Eukaryotic initiation factor 4A [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: inf-1
Official Full Name: Eukaryotic initiation factor 4A
Primary source: WormBase:WBGene00002083
Locus tag: CELE_F57B9.6
See related: AllianceGenome:WB:WBGene00002083
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable translation initiation factor activity. Predicted to be involved in cytoplasmic translational initiation. Predicted to be located in P granule. Predicted to be active in cytoplasmic stress granule. Is expressed in germ line; intestine; neurons; and pharynx. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with hypotonia and speech delay. Orthologous to several human genes including EIF4A1 (eukaryotic translation initiation factor 4A1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See inf-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 5

Sequence:: Chromosome: III; NC_003281.10 (6930134..6931953)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F57B9.6 (e-PCR)
- UniSTS:311904

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cytoplasmic translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in P granule	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasmic stress granule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Eukaryotic initiation factor 4A

NP_001022623.1

Confirmed by transcript evidence

NP_001022624.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

6930134..6931953

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027452.4 → NP_001022623.1 Eukaryotic initiation factor 4A [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022623.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P27639, Q4TTC4

Conserved Domains (3) summary

PTZ00424
Location:5 → 402

PTZ00424; helicase 45; Provisional

cd00079
Location:242 → 371

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cd00268
Location:31 → 231

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
NM_001027453.4 → NP_001022624.1 Eukaryotic initiation factor 4A [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022624.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P27639

Conserved Domains (1) summary

cd00079
Location:1 → 84

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...