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    mes-3 Polycomb protein mes-3 [ Caenorhabditis elegans ]

    Gene ID: 172123, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mes-3
    Official Full Name
    Polycomb protein mes-3
    Primary source
    WormBase:WBGene00003221
    Locus tag
    CELE_F54C1.3
    See related
    AllianceGenome:WB:WBGene00003221
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in regulation of gene expression. Located in nucleus. Part of PcG protein complex and nucleosome. Is expressed in several structures, including AB; C; D; E; and germ line. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mes-3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    15
    Sequence:
    Chromosome: I; NC_003279.8 (4996835..5003202)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene CILiary localization Neighboring gene Tetratricopeptide repeat protein 30 homolog Neighboring gene Decapping nuclease dom-3 Neighboring gene Uncharacterized protein Neighboring gene Sperm Specific Transcript

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The MES-2/MES-3/MES-6 complex and regulation of histone H3 methylation in C. elegans. Bender LB, et al. Curr Biol, 2004 Sep 21. PMID 15380065
    2. Chromatin domains rich in inheritance. Reinberg D, et al. Science, 2018 Jul 6. PMID 29976815
    3. The onset of C. elegans dosage compensation is linked to the loss of developmental plasticity. Custer LM, et al. Dev Biol, 2014 Jan 15. PMID 24252776, Free PMC Article
    4. Regulation of the different chromatin states of autosomes and X chromosomes in the germ line of C. elegans. Fong Y, et al. Science, 2002 Jun 21. PMID 12077420, Free PMC Article
    5. The Polycomb group in Caenorhabditis elegans and maternal control of germline development. Korf I, et al. Development, 1998 Jul. PMID 9609830

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. mes-3 represses Hox expression, causing anteroposterior transformations and disrupts Hox-dependent neuroblast migration.
      Title: Polycomb group regulation of Hox gene expression in C. elegans.
    2. mes-3 mutants suppress mab-3.
      Title: Finally, worm polycomb-like genes meet Hox regulation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of PcG protein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of nucleosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Polycomb protein mes-3
    NP_001021492.1
    • Confirmed by transcript evidence
    NP_001361974.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      4996835..5003202
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001374884.2 → NP_001361974.1  Polycomb protein mes-3 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G8JY65

    2. NM_001026321.4 → NP_001021492.1  Polycomb protein mes-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021492.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91324, Q10665
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q10665.2

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