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    lig-1 DNA ligase 1 [ Caenorhabditis elegans ]

    Gene ID: 179502, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lig-1
    Official Full Name
    DNA ligase 1
    Primary source
    WormBase:WBGene00002985
    Locus tag
    CELE_C29A12.3
    See related
    AllianceGenome:WB:WBGene00002985
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA ligase (ATP) activity. Predicted to be involved in DNA ligation and Okazaki fragment processing involved in mitotic DNA replication. Predicted to be active in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in inherited metabolic disorder and primary immunodeficiency disease. Orthologous to human LIG1 (DNA ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lig-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (10814106..10816718)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Transposase Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dna2 requirement for normal reproduction of Caenorhabditis elegans is temperature-dependent. Lee KH, et al. Mol Cells, 2003 Feb 28. PMID 12661765
    2. Predictive models of molecular machines involved in Caenorhabditis elegans early embryogenesis. Gunsalus KC, et al. Nature, 2005 Aug 11. PMID 16094371
    3. Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation. Oh SW, et al. Nat Genet, 2006 Feb. PMID 16380712
    4. The DREAM complex functions as conserved master regulator of somatic DNA-repair capacities. Bujarrabal-Dueso A, et al. Nat Struct Mol Biol, 2023 Apr. PMID 36959262, Free PMC Article
    5. Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Kamath RS, et al. Nature, 2003 Jan 16. PMID 12529635

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA ligase (ATP) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA ligase (ATP) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA ligation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Okazaki fragment processing involved in mitotic DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lagging strand elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA ligase 1
    NP_741625.2
    • Confirmed by transcript evidence
    NP_741626.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10814106..10816718
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171538.6 → NP_741626.2  DNA ligase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741626.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27474
      Conserved Domains (1) summary
      pfam04675
      Location:20 → 190
      DNA_ligase_A_N; DNA ligase N terminus

    2. NM_171537.6 → NP_741625.2  DNA ligase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741625.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27474, Q8MQB3
      Conserved Domains (4) summary
      cd07969
      Location:473 → 618
      OBF_DNA_ligase_I; The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase I is a DNA-binding module that is part of the catalytic core unit
      cd07900
      Location:252 → 468
      Adenylation_DNA_ligase_I_Euk; Adenylation domain of eukaryotic DNA Ligase I
      TIGR00574
      Location:77 → 617
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      pfam04675
      Location:20 → 190
      DNA_ligase_A_N; DNA ligase N terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q27474.2

    Gene LinkOut

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