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    rde-2 CABIT domain-containing protein;SH2 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172473, updated on 2-Nov-2024

    Summary

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    Official Symbol
    rde-2
    Official Full Name
    CABIT domain-containing protein;SH2 domain-containing protein
    Primary source
    WormBase:WBGene00004324
    Locus tag
    CELE_F21C3.4
    See related
    AllianceGenome:WB:WBGene00004324
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in meiotic chromosome segregation; regulatory ncRNA-mediated post-transcriptional gene silencing; and siRNA processing. Located in cytosol and mutator focus. Is expressed in germ line. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See rde-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (7280466..7282924, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Small integral membrane protein Neighboring gene ncRNA Neighboring gene Histidine triad nucleotide-binding protein 1 Neighboring gene putative prefoldin subunit 6 Neighboring gene DUF4200 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A heritable antiviral RNAi response limits Orsay virus infection in Caenorhabditis elegans N2. Sterken MG, et al. PLoS One, 2014. PMID 24587016, Free PMC Article
    2. Lack of pairing during meiosis triggers multigenerational transgene silencing in Caenorhabditis elegans. Leopold LE, et al. Proc Natl Acad Sci U S A, 2015 May 19. PMID 25941370, Free PMC Article
    3. RDE-2 interacts with MUT-7 to mediate RNA interference in Caenorhabditis elegans. Tops BB, et al. Nucleic Acids Res, 2005. PMID 15653635, Free PMC Article
    4. Genetic requirements for inheritance of RNAi in C. elegans. Grishok A, et al. Science, 2000 Mar 31. PMID 10741970
    5. RNAi protects the Caenorhabditis elegans germline against transposition. Vastenhouw NL, et al. Trends Genet, 2004 Jul. PMID 15219396

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNA interference proteins and MUT-7/RDE-2 function together in parallel pathways and/or as multiprotein complexes.
      Title: Caenorhabditis elegans ABCRNAi transporters interact genetically with rde-2 and mut-7.
    2. Interaction between RDE-2 and MUT-7 is required for efficient RNA interference.
      Title: RDE-2 interacts with MUT-7 to mediate RNA interference in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in meiotic chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in siRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mutator focus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CABIT domain-containing protein;SH2 domain-containing protein
    NP_001021398.1
    • Confirmed by transcript evidence
    NP_001021399.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7280466..7282924 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026228.4 → NP_001021399.1  CABIT domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021399.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q58AA4

    2. NM_001026227.3 → NP_001021398.1  SH2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021398.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19672
    Nucleotide Protein
    Heading Accession and Version

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