Mettl17 methyltransferase like 17 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mettl17provided by MGI
Official Full Name: methyltransferase like 17provided by MGI
Primary source: MGI:MGI:1098577
See related: Ensembl:ENSMUSG00000004561 AllianceGenome:MGI:1098577
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mett11d1; D14Ertd209e; 2310032K15Rik
Summary: Enables S-adenosyl-L-methionine binding activity and mitochondrial ribosome binding activity. Involved in ribosomal small subunit biogenesis. Located in mitochondrial matrix. Orthologous to human METTL17 (methyltransferase like 17). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 18.3), CNS E14 (RPKM 17.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C2; 14 26.71 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (52122375..52129325)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (51884842..51891868)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

RH126603 (e-PCR)
- UniSTS:167129

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables 4 iron, 4 sulfur cluster binding	ISO Inferred from Sequence Orthology more info
enables S-adenosyl-L-methionine binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables mitochondrial ribosome binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in mitochondrial small ribosomal subunit assembly	ISO Inferred from Sequence Orthology more info
involved_in ribosomal small subunit biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ribosome assembly protein METTL17, mitochondrial

Names: methyltransferase 11 domain containing 1; methyltransferase 11 domain-containing protein 1; methyltransferase-like protein 17, mitochondrial; protein RSM22 homolog, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001029990.2 → NP_001025161.1 ribosome assembly protein METTL17, mitochondrial precursor

See identical proteins and their annotated locations for NP_001025161.1

Status: VALIDATED

Source sequence(s)

AC125087

Consensus CDS

CCDS36913.1

UniProtKB/Swiss-Prot

B2RSP2, Q3U2U7

UniProtKB/TrEMBL

E9Q7K9

Related

ENSMUSP00000047720.7, ENSMUST00000047899.13

Conserved Domains (1) summary

cl17173
Location:156 → 442

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...