Tefm transcription elongation factor, mitochondrial [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tefmprovided by RGD
Official Full Name: transcription elongation factor, mitochondrialprovided by RGD
Primary source: RGD:1306595
See related: EnsemblRapid:ENSRNOG00000004000 AllianceGenome:RGD:1306595
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1306595
Summary: Predicted to enable DNA polymerase processivity factor activity. Predicted to be involved in mitochondrial transcription and oxidative phosphorylation. Predicted to be located in mitochondrial matrix. Predicted to be part of ribonucleoprotein complex. Predicted to be active in mitochondrial nucleoid. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency. Orthologous to human TEFM (transcription elongation factor, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 125.7), Kidney (RPKM 94.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q25

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (65617547..65622042, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (65119657..65124233, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (67476006..67478830, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH138002 (e-PCR)
- UniSTS:220089

RH140957 (e-PCR)
- UniSTS:222958

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA polymerase processivity factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA polymerase processivity factor activity	IEA Inferred from Electronic Annotation more info
enables DNA polymerase processivity factor activity	ISO Inferred from Sequence Orthology more info
enables DNA polymerase processivity factor activity	ISS Inferred from Sequence or Structural Similarity more info
NOT enables crossover junction DNA endonuclease activity	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
NOT involved_in mitochondrial DNA replication	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial transcription	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in oxidative phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in oxidative phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in oxidative phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in transcription elongation by mitochondrial RNA polymerase	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrial nucleoid	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial nucleoid	IEA Inferred from Electronic Annotation more info
located_in mitochondrial nucleoid	ISO Inferred from Sequence Orthology more info
located_in mitochondrial nucleoid	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: transcription elongation factor, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.