scn3b sodium channel, voltage-gated, type III, beta [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: scn3bprovided by ZNC
Official Full Name: sodium channel, voltage-gated, type III, betaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070920-2
See related: Ensembl:ENSDARG00000062359 AllianceGenome:ZFIN:ZDB-GENE-070920-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable sodium channel inhibitor activity and transmembrane transporter binding activity. Predicted to be involved in regulation of heart rate by cardiac conduction; regulation of sodium ion transmembrane transporter activity; and ventricular cardiac muscle cell action potential. Predicted to act upstream of or within monoatomic ion transmembrane transport and sodium ion transport. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated sodium channel complex. Is expressed in atrium; brain; cardiac ventricle; and eye. Human ortholog(s) of this gene implicated in Brugada syndrome 7. Orthologous to human SCN3B (sodium voltage-gated channel beta subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (22131626..22147860, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (22197711..22212136, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables sodium channel activity	IEA Inferred from Electronic Annotation more info
enables sodium channel inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium channel regulator activity	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in membrane depolarization during cardiac muscle cell action potential	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of heart rate by cardiac conduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in ventricular cardiac muscle cell action potential	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of voltage-gated sodium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated sodium channel complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sodium channel regulatory subunit beta-3

Names: voltage-gated sodium channel beta 3 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080802.1 → NP_001074271.1 sodium channel regulatory subunit beta-3 precursor

See identical proteins and their annotated locations for NP_001074271.1

Status: PROVISIONAL

Source sequence(s)

DQ489730

UniProtKB/TrEMBL

Q06W27

Conserved Domains (2) summary

smart00410
Location:30 → 128

IG_like; Immunoglobulin like

pfam07686
Location:34 → 127

V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007126.7 Reference GRCz11 Primary Assembly

Range

22131626..22147860 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009291662.3 → XP_009289937.1 sodium channel regulatory subunit beta-3 isoform X2

UniProtKB/TrEMBL

A0A8M3APT8

Conserved Domains (2) summary

smart00410
Location:51 → 149

IG_like; Immunoglobulin like

pfam07686
Location:55 → 148

V-set; Immunoglobulin V-set domain
XM_009291661.3 → XP_009289936.1 sodium channel regulatory subunit beta-3 isoform X1

UniProtKB/TrEMBL

A0A8M3ASQ5, F8W4B3

Related

ENSDARP00000123929.1, ENSDART00000149784.2

Conserved Domains (2) summary

smart00410
Location:51 → 149

IG_like; Immunoglobulin like

pfam07686
Location:55 → 148

V-set; Immunoglobulin V-set domain
XM_068213570.1 → XP_068069671.1 sodium channel regulatory subunit beta-3 isoform X3