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    sh3rf2 SH3 domain containing ring finger 2 [ Danio rerio (zebrafish) ]

    Gene ID: 100537944, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sh3rf2provided by ZNC
    Official Full Name
    SH3 domain containing ring finger 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-141212-301
    See related
    Ensembl:ENSDARG00000101178 AllianceGenome:ZFIN:ZDB-GENE-141212-301
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-42a21.3; si:dkey-42a21.4
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in positive regulation of JNK cascade; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and protein ubiquitination. Orthologous to human SH3RF2 (SH3 domain containing ring finger 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sh3rf2 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (23871966..23967097)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (23631271..23669919)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) Neighboring gene potassium channel tetramerization domain containing 16a Neighboring gene uncharacterized LOC137487587 Neighboring gene kinesin family member 3A Neighboring gene interleukin 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase SH3RF2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      23871966..23967097
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068213335.1 → XP_068069436.1  E3 ubiquitin-protein ligase SH3RF2

      UniProtKB/TrEMBL
      A0A2R9YJN1, A0A8M9QGN1
      Related
      ENSDARP00000134947.2, ENSDART00000172149.2

    2. XM_021481154.2 → XP_021336829.1  E3 ubiquitin-protein ligase SH3RF2

      UniProtKB/TrEMBL
      A0A2R9YJN1, A0A8M9QGN1
      Related
      ENSDARP00000140215.2, ENSDART00000159582.3
      Conserved Domains (2) summary
      cl17036
      Location:384 → 437
      SH3; Src Homology 3 domain superfamily
      cl17238
      Location:8 → 54
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394908.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      232193..270795
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009291057.4 → XP_009289332.1  E3 ubiquitin-protein ligase SH3RF2

      UniProtKB/TrEMBL
      A0A2R9YJN1, A0A8M9QGN1
      Conserved Domains (2) summary
      cl17036
      Location:384 → 437
      SH3; Src Homology 3 domain superfamily
      cl17238
      Location:8 → 54
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395314.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      357593..452724
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068219324.1 → XP_068075425.1  E3 ubiquitin-protein ligase SH3RF2

      UniProtKB/TrEMBL
      A0A2R9YJN1, A0A8M9QGN1

    2. XM_021474306.2 → XP_021329981.1  E3 ubiquitin-protein ligase SH3RF2

      UniProtKB/TrEMBL
      A0A2R9YJN1, A0A8M9QGN1
      Conserved Domains (2) summary
      cl17036
      Location:384 → 437
      SH3; Src Homology 3 domain superfamily
      cl17238
      Location:8 → 54
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    Nucleotide Protein Strain
    Heading Accession and Version

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