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    Naif1 nuclear apoptosis inducing factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 71254, updated on 27-Nov-2024

    Summary

    Official Symbol
    Naif1provided by MGI
    Official Full Name
    nuclear apoptosis inducing factor 1provided by MGI
    Primary source
    MGI:MGI:1918504
    See related
    Ensembl:ENSMUSG00000039164 AllianceGenome:MGI:1918504
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310007O20Rik; 4933440H19Rik
    Summary
    Predicted to be involved in negative regulation of cell growth and regulation of mitochondrial membrane permeability involved in apoptotic process. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in nucleus. Orthologous to human NAIF1 (nuclear apoptosis inducing factor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 9.3), adrenal adult (RPKM 8.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Naif1 in Genome Data Viewer
    Location:
    2 B; 2 22.09 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (32340469..32346969)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (32450457..32455476)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2612 Neighboring gene prostaglandin E synthase 2 Neighboring gene predicted gene 13413 Neighboring gene solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25 Neighboring gene STARR-positive B cell enhancer ABC_E4433 Neighboring gene STARR-positive B cell enhancer ABC_E120 Neighboring gene STARR-seq mESC enhancer starr_04193 Neighboring gene STARR-positive B cell enhancer ABC_E4434 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:32350767-32351080 Neighboring gene STARR-seq mESC enhancer starr_04196 Neighboring gene STARR-seq mESC enhancer starr_04197 Neighboring gene STARR-positive B cell enhancer ABC_E2613 Neighboring gene estrogen-induced osteoclastogenesis regulator 1 Neighboring gene STARR-positive B cell enhancer ABC_E4435 Neighboring gene dolichyl-phosphate mannosyltransferase subunit 2, regulatory

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    nuclear apoptosis-inducing factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_194335.3NP_919316.1  nuclear apoptosis-inducing factor 1

      See identical proteins and their annotated locations for NP_919316.1

      Status: VALIDATED

      Source sequence(s)
      AL928710
      Consensus CDS
      CCDS15916.1
      UniProtKB/Swiss-Prot
      A2ASZ4, Q6PFD7, Q8CEZ2
      Related
      ENSMUSP00000048764.3, ENSMUST00000048431.3
      Conserved Domains (1) summary
      pfam13873
      Location:882
      Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      32340469..32346969
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)