U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    Upb1 ureidopropionase, beta [ Mus musculus (house mouse) ]

    Gene ID: 103149, updated on 27-Nov-2024

    Summary

    Official Symbol
    Upb1provided by MGI
    Official Full Name
    ureidopropionase, betaprovided by MGI
    Primary source
    MGI:MGI:2143535
    See related
    Ensembl:ENSMUSG00000033427 AllianceGenome:MGI:2143535
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    This gene encodes an enzyme that catalyzes the conversion of N-carbamyl-beta-aminoisobutyric acid and N-carbamyl-beta-alanine to beta-aminoisobutyric acid or beta-alanine. Mutations in the related gene in human have been associated with beta-ureidopropionase deficiency. [provided by RefSeq, Dec 2013]
    Expression
    Biased expression in liver adult (RPKM 40.3), kidney adult (RPKM 20.2) and 3 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Upb1 in Genome Data Viewer
    Location:
    10 C1; 10 38.53 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (75242745..75277513)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (75406911..75441679)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27152 Neighboring gene ribosomal protein, large, P0 pseudogene Neighboring gene STARR-seq mESC enhancer starr_27153 Neighboring gene predicted gene, 40694 Neighboring gene STARR-positive B cell enhancer ABC_E9345 Neighboring gene RIKEN cDNA 4933407G14 gene Neighboring gene STARR-positive B cell enhancer ABC_E6873 Neighboring gene STARR-positive B cell enhancer ABC_E9793 Neighboring gene guanylyl cyclase domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-ureidopropionase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables beta-ureidopropionase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables beta-ureidopropionase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables beta-ureidopropionase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in CMP catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in UMP catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in beta-alanine biosynthetic process via 3-ureidopropionate IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in beta-alanine biosynthetic process via 3-ureidopropionate ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in beta-alanine biosynthetic process via 3-ureidopropionate ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in beta-alanine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dCMP catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dTMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in dUMP catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in liver development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in liver development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homooligomerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein homotetramerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pyrimidine nucleoside catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pyrimidine nucleoside catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    beta-ureidopropionase
    Names
    N-carbamoyl-beta-alanine amidohydrolase
    beta-alanine synthase
    NP_598756.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133995.4NP_598756.1  beta-ureidopropionase

      See identical proteins and their annotated locations for NP_598756.1

      Status: REVIEWED

      Source sequence(s)
      AC137067, AK149480
      Consensus CDS
      CCDS23925.1
      UniProtKB/Swiss-Prot
      Q8R1K8, Q8VC97
      UniProtKB/TrEMBL
      Q3UEK4
      Related
      ENSMUSP00000049342.8, ENSMUST00000039925.8
      Conserved Domains (1) summary
      cd07587
      Location:9371
      ML_beta-AS; mammalian-like beta-alanine synthase (beta-AS) and similar proteins (class 5 nitrilases)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      75242745..75277513
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)