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    Bmerb1 bMERB domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360459, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bmerb1provided by RGD
    Official Full Name
    bMERB domain containing 1provided by RGD
    Primary source
    RGD:1305733
    See related
    EnsemblRapid:ENSRNOG00000003198 AllianceGenome:RGD:1305733
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305733
    Summary
    Predicted to be involved in negative regulation of microtubule depolymerization. Predicted to act upstream of or within negative regulation of cell motility involved in cerebral cortex radial glia guided migration. Predicted to be active in microtubule cytoskeleton. Orthologous to human BMERB1 (bMERB domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 525.3) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bmerb1 in Genome Data Viewer
    Location:
    10q11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (2286999..2453890, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (1779834..1946586, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (3411380..3570689)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily C member 1, pseudogene 1 Neighboring gene uncharacterized LOC134480740 Neighboring gene large ribosomal subunit protein uL13-like Neighboring gene meiosis regulator and mRNA stability factor 1 like 1 Neighboring gene nuclear receptor coactivator 4, pseudogene 1 Neighboring gene MPV17 mitochondrial inner membrane protein like Neighboring gene pyridoxal-dependent decarboxylase domain containing 1 Neighboring gene N-terminal asparagine amidase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The newly identified migration inhibitory protein regulates the radial migration in the developing neocortex. Zhang S, et al. Sci Rep, 2014 Aug 7. PMID 25099998, Free PMC Article
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109261

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of cell motility involved in cerebral cortex radial glia guided migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell motility involved in cerebral cortex radial glia guided migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    bMERB domain-containing protein 1
    Names
    uncharacterized protein C16orf45 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014114.1 → NP_001014136.1  bMERB domain-containing protein 1

      See identical proteins and their annotated locations for NP_001014136.1

      Status: PROVISIONAL

      Source sequence(s)
      BC089943
      UniProtKB/Swiss-Prot
      Q5FVJ5
      UniProtKB/TrEMBL
      A6K4E9
      Related
      ENSRNOP00000004346.6, ENSRNOT00000004346.8
      Conserved Domains (1) summary
      cl23748
      Location:63 → 142
      DUF3585; Protein of unknown function (DUF3585)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      2286999..2453890 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086245.2 → XP_038942173.1  bMERB domain-containing protein 1 isoform X1

      Conserved Domains (1) summary
      cl23748
      Location:50 → 142
      DUF3585; Protein of unknown function (DUF3585)

    2. XM_063269270.1 → XP_063125340.1  bMERB domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A6K4E9
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5FVJ5.1 GenPept UniProtKB/Swiss-Prot:Q5FVJ5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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