ICS2 isochorismate synthase 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ICS2
Official Full Name: isochorismate synthase 2
Primary source: TAIR:AT1G18870
Locus tag: AT1G18870
See related: Araport:AT1G18870
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS ISOCHORISMATE SYNTHASE 2; ATICS2; F6A14.3; F6A14_3; isochorismate synthase 2
Summary: Encodes a protein with isochorismate synthase activity involved in phylloquinone biosynthesis. Mutant studies of this gene's function suggest that its function is redundant with that of ICS1 (AT1G7410).
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Genomic context

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See ICS2 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 15

Sequence:: Chromosome: 1; NC_003070.9 (6515373..6519395)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that AtICS1 and AtICS2 (here, expressed as hexahistidine fusion proteins) are Mg2+-dependent with similar temperature optima (ca. 33 C) and similar Km values for chorismate, but reaction rates are greater for AtICS1 than for AtICS2; neither enzyme exhibits isochorismate pyruvate lyase activity.
Title: The biochemical properties of the two Arabidopsis thaliana isochorismate synthases.
participates in the synthesis of salicylic acid, but in limited amounts that become clearly detectable only when ICS1 is lacking
Title: Characterization and biological function of the ISOCHORISMATE SYNTHASE2 gene of Arabidopsis.

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General gene information

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Homology

Orthologs from OrthoDB

NM_001160879.1

Supported by ESTs:

NM_001332377.1

Supported by ESTs:

NM_101744.7

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables isochorismate synthase activity	IEA Inferred from Electronic Annotation more info
enables isochorismate synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phylloquinone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in salicylic acid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in plastid	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: isochorismate synthase 2

NP_001154351.1

isochorismate synthase 2 (ICS2); CONTAINS InterPro DOMAIN/s: Chorismate binding, C-terminal (InterPro:IPR015890), ADC synthase (InterPro:IPR005801), Isochorismate synthase (InterPro:IPR004561); BEST Arabidopsis thaliana protein match is: ADC synthase superfamily protein (TAIR:AT1G74710.1); Has 14307 Blast hits to 14303 proteins in 2517 species: Archae - 246; Bacteria - 10487; Metazoa - 5; Fungi - 253; Plants - 208; Viruses - 0; Other Eukaryotes - 3108 (source: NCBI BLink).

NP_173321.4

isochorismate synthase 2 (ICS2); CONTAINS InterPro DOMAIN/s: Chorismate binding, C-terminal (InterPro:IPR015890), ADC synthase (InterPro:IPR005801), Isochorismate synthase (InterPro:IPR004561); BEST Arabidopsis thaliana protein match is: ADC synthase superfamily protein (TAIR:AT1G74710.1); Has 14372 Blast hits to 14368 proteins in 2522 species: Archae - 246; Bacteria - 10572; Metazoa - 5; Fungi - 239; Plants - 212; Viruses - 0; Other Eukaryotes - 3098 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

6515373..6519395

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_101744.7 → NP_173321.4 isochorismate synthase 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_173321.4

Status: REVIEWED

UniProtKB/Swiss-Prot

B2LWF5, Q9M9V6

UniProtKB/TrEMBL

A0A178WHJ9, A0A5S9V2Z1, A0A654EG33

Conserved Domains (1) summary

PLN02786
Location:26 → 562

PLN02786; isochorismate synthase
NM_001332377.1 → NP_001321112.1 isochorismate synthase 2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178WHJ9, A0A1P8APX0
NM_001160879.1 → NP_001154351.1 isochorismate synthase 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001154351.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A7G2DRL4, F4IDX8

Conserved Domains (2) summary

PLN02786
Location:1 → 512

PLN02786; isochorismate synthase

TIGR00543
Location:143 → 502

isochor_syn; isochorismate synthases