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    Ufsp2 UFM1-specific peptidase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361151, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ufsp2provided by RGD
    Official Full Name
    UFM1-specific peptidase 2provided by RGD
    Primary source
    RGD:1311161
    See related
    EnsemblRapid:ENSRNOG00000012087 AllianceGenome:RGD:1311161
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311161
    Summary
    Predicted to enable deUFMylase activity. Predicted to be involved in several processes, including negative regulation of proteolysis involved in protein catabolic process; regulation of intracellular estrogen receptor signaling pathway; and rescue of stalled ribosome. Predicted to be located in cytoplasm. Predicted to be active in endoplasmic reticulum and nucleus. Human ortholog(s) of this gene implicated in Beukes hip dysplasia and developmental and epileptic encephalopathy 106. Orthologous to human UFSP2 (UFM1 specific peptidase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 237.8), Liver (RPKM 173.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ufsp2 in Genome Data Viewer
    Location:
    16q11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (53004590..53023640, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (46272016..46291080, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (49465958..49484975, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene sorting nexin 25 Neighboring gene U6 spliceosomal RNA Neighboring gene Lrp2 binding protein Neighboring gene ankyrin repeat domain 37 Neighboring gene cilia and flagella associated protein 96 Neighboring gene coiled-coil domain containing 110 Neighboring gene PDZ and LIM domain 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structure of ubiquitin-fold modifier 1-specific protease UfSP2. Ha BH, et al. J Biol Chem, 2011 Mar 25. PMID 21228277, Free PMC Article
    2. Two novel ubiquitin-fold modifier 1 (Ufm1)-specific proteases, UfSP1 and UfSP2. Kang SH, et al. J Biol Chem, 2007 Feb 23. PMID 17182609
    3. Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cancer development. Yoo HM, et al. Mol Cell, 2014 Oct 23. PMID 25219498
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables deUFMylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deUFMylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deUFMylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables deUFMylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of proteolysis involved in protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of intracellular estrogen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of intracellular estrogen receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of type II interferon production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ufm1-specific protease 2
    NP_001014164.1
    XP_006253221.1
    XP_008769487.1
    XP_038950568.1
    XP_063131588.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014142.1 → NP_001014164.1  ufm1-specific protease 2

      See identical proteins and their annotated locations for NP_001014164.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083771
      UniProtKB/Swiss-Prot
      Q5XIB4
      UniProtKB/TrEMBL
      A0A8I6AQ70, A6JPQ2
      Related
      ENSRNOP00000016723.4, ENSRNOT00000016723.8
      Conserved Domains (1) summary
      pfam07910
      Location:272 → 453
      Peptidase_C78; Peptidase family C78

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      53004590..53023640 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094640.2 → XP_038950568.1  ufm1-specific protease 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AQ70
      Conserved Domains (1) summary
      pfam07910
      Location:251 → 432
      Peptidase_C78; Peptidase family C78

    2. XM_008771265.4 → XP_008769487.1  ufm1-specific protease 2 isoform X1

      See identical proteins and their annotated locations for XP_008769487.1

      UniProtKB/Swiss-Prot
      Q5XIB4
      UniProtKB/TrEMBL
      A0A8I6AQ70, A6JPQ2
      Conserved Domains (1) summary
      pfam07910
      Location:272 → 453
      Peptidase_C78; Peptidase family C78

    3. XM_063275518.1 → XP_063131588.1  ufm1-specific protease 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AQ70

    4. XM_006253159.3 → XP_006253221.1  ufm1-specific protease 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AQ70
      Conserved Domains (1) summary
      pfam07910
      Location:180 → 361
      Peptidase_C78; Peptidase family C78
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIB4.1 GenPept UniProtKB/Swiss-Prot:Q5XIB4

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