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    Midn midnolin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314623, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Midnprovided by RGD
    Official Full Name
    midnolinprovided by RGD
    Primary source
    RGD:1309629
    See related
    EnsemblRapid:ENSRNOG00000015434 AllianceGenome:RGD:1309629
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables kinase binding activity. Acts upstream of or within negative regulation of glucokinase activity and negative regulation of insulin secretion. Predicted to be located in cytosol and nucleolus. Predicted to be active in nucleus. Orthologous to human MIDN (midnolin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 59.5), Thymus (RPKM 55.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Midn in Genome Data Viewer
    Location:
    7q11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10198761..10210563, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9548100..9559605, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12414303..12426712, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 174 member C Neighboring gene cold inducible RNA binding protein Neighboring gene ATP synthase F1 subunit delta Neighboring gene CACN subunit beta associated regulatory protein Neighboring gene serine/threonine kinase 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transcriptome Analysis Reveals That Midnolin Regulates mRNA Expression Levels of Multiple Parkinson's Disease Causative Genes. Obara Y, et al. Biol Pharm Bull, 2018. PMID 29311479
    2. Novel nucleolar protein, midnolin, is expressed in the mesencephalon during mouse development. Tsukahara M, et al. Gene, 2000 Aug 22. PMID 10974535
    3. Midnolin is a novel regulator of parkin expression and is associated with Parkinson's Disease. Obara Y, et al. Sci Rep, 2017 Jul 19. PMID 28724963, Free PMC Article
    4. Identification of the ubiquitin-like domain of midnolin as a new glucokinase interaction partner. Hofmeister-Brix A, et al. J Biol Chem, 2013 Dec 13. PMID 24187134, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MIDN promotes the expression of parkin E3 ubiquitin ligase, and that MIDN loss can trigger Parkinson's disease-related pathogenic mechanisms.
      Title: Midnolin is a novel regulator of parkin expression and is associated with Parkinson's Disease.
    2. These findings indicate that MIDN regulates the expression of a wide variety of genes, including multiple Parkinson's Disease causative genes and is associated with Parkinson's Disease onset.
      Title: Transcriptome Analysis Reveals That Midnolin Regulates mRNA Expression Levels of Multiple Parkinson's Disease Causative Genes.
    3. midnolin plays a role in cellular signaling of adult tissues and regulates glucokinase enzyme activity in pancreatic beta cells
      Title: Identification of the ubiquitin-like domain of midnolin as a new glucokinase interaction partner.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of glucokinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of insulin secretion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteasomal ubiquitin-independent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    midnolin
    Names
    midbrain nucleolar protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191577.1 → NP_001178506.1  midnolin

      See identical proteins and their annotated locations for NP_001178506.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      D4AE48
      UniProtKB/TrEMBL
      A6K8Q2
      Related
      ENSRNOP00000057429.2, ENSRNOT00000060698.6
      Conserved Domains (1) summary
      cd01804
      Location:32 → 101
      Ubl_midnolin; ubiquitin-like (Ubl) domain found in midnolin and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      10198761..10210563 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240913.5 → XP_006240975.1  midnolin isoform X2

      UniProtKB/TrEMBL
      A6K8Q2
      Conserved Domains (2) summary
      cd01804
      Location:31 → 108
      midnolin_N; Ubiquitin-like domain of midnolin
      smart00213
      Location:32 → 100
      UBQ; Ubiquitin homologues

    2. XM_006240911.5 → XP_006240973.1  midnolin isoform X1

      See identical proteins and their annotated locations for XP_006240973.1

      UniProtKB/Swiss-Prot
      D4AE48
      UniProtKB/TrEMBL
      A6K8Q2
      Conserved Domains (1) summary
      cd01804
      Location:32 → 101
      Ubl_midnolin; ubiquitin-like (Ubl) domain found in midnolin and similar proteins

    3. XM_017594815.3 → XP_017450304.1  midnolin isoform X4

      UniProtKB/TrEMBL
      A6K8Q1

    4. XM_006240914.5 → XP_006240976.1  midnolin isoform X3

      UniProtKB/TrEMBL
      A0A8I6A3L5, A6K8Q1
      Related
      ENSRNOP00000085295.1, ENSRNOT00000102859.2
      Conserved Domains (2) summary
      cd01804
      Location:31 → 108
      midnolin_N; Ubiquitin-like domain of midnolin
      smart00213
      Location:32 → 100
      UBQ; Ubiquitin homologues

    5. XM_006240912.5 → XP_006240974.1  midnolin isoform X1

      See identical proteins and their annotated locations for XP_006240974.1

      UniProtKB/Swiss-Prot
      D4AE48
      UniProtKB/TrEMBL
      A6K8Q2
      Conserved Domains (1) summary
      cd01804
      Location:32 → 101
      Ubl_midnolin; ubiquitin-like (Ubl) domain found in midnolin and similar proteins

    6. XM_008765097.4 → XP_008763319.1  midnolin isoform X5

      UniProtKB/TrEMBL
      A6K8Q2
      Conserved Domains (1) summary
      cl00155
      Location:2 → 31
      UBQ; Ubiquitin-like proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D4AE48.1 GenPept UniProtKB/Swiss-Prot:D4AE48

    Gene LinkOut

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