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    Ppp1r16b protein phosphatase 1, regulatory subunit 16B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680616, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ppp1r16bprovided by RGD
    Official Full Name
    protein phosphatase 1, regulatory subunit 16Bprovided by RGD
    Primary source
    RGD:1589460
    See related
    EnsemblRapid:ENSRNOG00000015614 AllianceGenome:RGD:1589460
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable enzyme inhibitor activity and myosin phosphatase regulator activity. Predicted to be involved in several processes, including establishment of endothelial barrier; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; and regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in several cellular components, including nuclear speck; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human PPP1R16B (protein phosphatase 1 regulatory subunit 16B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 121.7), Brain (RPKM 72.7) and 8 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ppp1r16b in Genome Data Viewer
    Location:
    3q42
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (167743518..167839511)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (147323652..147419658)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (155160474..155267002)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 32 member 1 Neighboring gene actin related protein 5 Neighboring gene 60S ribosomal protein L13-like Neighboring gene family with sequence similarity 83, member D Neighboring gene DEAH-box helicase 35

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables myosin phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein phosphatase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell projection ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein phosphatase 1 regulatory inhibitor subunit 16B
    Names
    protein phosphatase 1, regulatory (inhibitor) subunit 16B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191072.1NP_001178001.1  protein phosphatase 1 regulatory inhibitor subunit 16B

      See identical proteins and their annotated locations for NP_001178001.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      D4AA72
      Related
      ENSRNOP00000021133.4, ENSRNOT00000021133.9
      Conserved Domains (3) summary
      PHA03095
      Location:71301
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:7198
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:72164
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      167743518..167839511
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008762383.4XP_008760605.1  protein phosphatase 1 regulatory inhibitor subunit 16B isoform X1

      See identical proteins and their annotated locations for XP_008760605.1

      UniProtKB/TrEMBL
      D4AA72
      Conserved Domains (3) summary
      PHA03095
      Location:71301
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:7198
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:72164
      Ank_2; Ankyrin repeats (3 copies)
    2. XM_017592039.3XP_017447528.1  protein phosphatase 1 regulatory inhibitor subunit 16B isoform X2

    3. XM_008762384.3XP_008760606.1  protein phosphatase 1 regulatory inhibitor subunit 16B isoform X1

      See identical proteins and their annotated locations for XP_008760606.1

      UniProtKB/TrEMBL
      D4AA72
      Conserved Domains (3) summary
      PHA03095
      Location:71301
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:7198
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:72164
      Ank_2; Ankyrin repeats (3 copies)
    4. XM_039105844.2XP_038961772.1  protein phosphatase 1 regulatory inhibitor subunit 16B isoform X1

      UniProtKB/TrEMBL
      D4AA72
      Conserved Domains (3) summary
      PHA03095
      Location:71301
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:7198
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:72164
      Ank_2; Ankyrin repeats (3 copies)
    5. XM_008762385.3XP_008760607.1  protein phosphatase 1 regulatory inhibitor subunit 16B isoform X1

      See identical proteins and their annotated locations for XP_008760607.1

      UniProtKB/TrEMBL
      D4AA72
      Conserved Domains (3) summary
      PHA03095
      Location:71301
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:7198
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:72164
      Ank_2; Ankyrin repeats (3 copies)