Pip5k1a phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pip5k1aprovided by RGD
Official Full Name: phosphatidylinositol-4-phosphate 5-kinase, type 1, alphaprovided by RGD
Primary source: RGD:1306127
See related: EnsemblRapid:ENSRNOG00000021068 AllianceGenome:RGD:1306127
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pip5k1b
Summary: Predicted to enable 1-phosphatidylinositol-4-phosphate 5-kinase activity and kinase binding activity. Predicted to be involved in several processes, including activation of GTPase activity; focal adhesion assembly; and ruffle assembly. Predicted to act upstream of or within fibroblast migration and phosphatidylinositol biosynthetic process. Predicted to be located in several cellular components, including lamellipodium; nuclear speck; and ruffle membrane. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Predicted to be active in plasma membrane. Orthologous to human PIP5K1A (phosphatidylinositol-4-phosphate 5-kinase type 1 alpha). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 124.7), Muscle (RPKM 98.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (185317319..185361859, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (182628299..182671584, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (196227669..196270949, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphatidylinositol-4-phosphate 5-kinase type 1alpha attenuates Abeta production by promoting non-amyloidogenic processing of amyloid precursor protein.
Title: Phosphatidylinositol-4-phosphate 5-kinase type 1α attenuates Aβ production by promoting non-amyloidogenic processing of amyloid precursor protein.

Submit: New GeneRIF Correction

General gene information

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Markers

RH127674 (e-PCR)
- UniSTS:210984

RH143262 (e-PCR)
- UniSTS:232509

A005O11 (e-PCR)
- UniSTS:44682

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity	IEA Inferred from Electronic Annotation more info
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity	ISO Inferred from Sequence Orthology more info
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase binding	IEA Inferred from Electronic Annotation more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in activation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in cell chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in fibroblast migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fibroblast migration	ISO Inferred from Sequence Orthology more info
involved_in focal adhesion assembly	IEA Inferred from Electronic Annotation more info
involved_in focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphatidylinositol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphatidylinositol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in ruffle assembly	IEA Inferred from Electronic Annotation more info
involved_in ruffle assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
part_of mRNA cleavage and polyadenylation specificity factor complex	IEA Inferred from Electronic Annotation more info
part_of mRNA cleavage and polyadenylation specificity factor complex	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

Names: 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase; PIP5K1-alpha; PIP5KIalpha; phosphatidylinositol 4-phosphate 5-kinase type I alpha; phosphatidylinositol-4-phosphate 5-kinase, type 1 beta; ptdIns(4)P-5-kinase 1 alpha

NP_001036086.2

EC 2.7.1.68

XP_008759537.1

EC 2.7.1.68

XP_008759538.1

EC 2.7.1.68

XP_038958707.1

EC 2.7.1.68

XP_038958708.1

EC 2.7.1.68

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042621.2 → NP_001036086.2 phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

D3ZSI8

UniProtKB/TrEMBL

A0A8I6ANU4

Related

ENSRNOP00000028609.6, ENSRNOT00000028609.6

Conserved Domains (1) summary

cd17306
Location:64 → 439

PIPKc_PIP5K1A_like; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1alpha) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

185317319..185361859 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008761316.2 → XP_008759538.1 phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X4

See identical proteins and their annotated locations for XP_008759538.1

UniProtKB/TrEMBL

A0A8I6A5T8, A0A8I6ANU4, A6K2U4

Conserved Domains (1) summary

smart00330
Location:94 → 434

PIPKc; Phosphatidylinositol phosphate kinases
XM_008761315.2 → XP_008759537.1 phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X3

UniProtKB/TrEMBL

A0A8I6ANU4

Conserved Domains (1) summary

smart00330
Location:95 → 435

PIPKc; Phosphatidylinositol phosphate kinases
XM_039102780.2 → XP_038958708.1 phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X2

UniProtKB/TrEMBL

A0A8I6ANU4, A0A8L2QH45

Related

ENSRNOP00000086696.2, ENSRNOT00000119756.2

Conserved Domains (1) summary

cd17306
Location:78 → 453

PIPKc_PIP5K1A_like; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1alpha) and similar proteins
XM_039102779.2 → XP_038958707.1 phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1

UniProtKB/TrEMBL

A0A8I6ANU4

Conserved Domains (1) summary

cd17306
Location:79 → 454

PIPKc_PIP5K1A_like; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1alpha) and similar proteins