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    Ermard ER membrane-associated RNA degradation [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361485, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ermardprovided by RGD
    Official Full Name
    ER membrane-associated RNA degradationprovided by RGD
    Primary source
    RGD:1309374
    See related
    EnsemblRapid:ENSRNOG00000015230 AllianceGenome:RGD:1309374
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309374; RGD1562376
    Summary
    Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human ERMARD (ER membrane associated RNA degradation). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 87.1), Adrenal (RPKM 75.9) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ermard in Genome Data Viewer
    Location:
    1q12
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (64656414..64675803)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (55983312..56004569)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (56982742..57008076)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 6 open reading frame 120 Neighboring gene PHD finger protein 10 Neighboring gene dynein light chain Tctex-type 2 Neighboring gene uncharacterized LOC120099128 Neighboring gene uncharacterized LOC102550786

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125089

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    endoplasmic reticulum membrane-associated RNA degradation protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419620.1 → NP_001406549.1  endoplasmic reticulum membrane-associated RNA degradation protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      D3ZU62, Q3B8R1
      UniProtKB/TrEMBL
      A0A8I6A0K4
      Related
      ENSRNOP00000056590.4, ENSRNOT00000059845.6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      64656414..64675803
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039100111.2 → XP_038956039.1  endoplasmic reticulum membrane-associated RNA degradation protein isoform X8

      Conserved Domains (1) summary
      pfam13910
      Location:133 → 205
      DUF4209; Domain of unknown function (DUF4209)

    2. XM_006227972.5 → XP_006228034.1  endoplasmic reticulum membrane-associated RNA degradation protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6A0K4
      Conserved Domains (1) summary
      pfam13910
      Location:133 → 205
      DUF4209; Domain of unknown function (DUF4209)

    3. XM_039100085.2 → XP_038956013.1  endoplasmic reticulum membrane-associated RNA degradation protein isoform X2

      UniProtKB/TrEMBL
      A0A8I6A0K4
      Conserved Domains (1) summary
      pfam13910
      Location:133 → 214
      DUF4209; Domain of unknown function (DUF4209)

    4. XM_063266197.1 → XP_063122267.1  endoplasmic reticulum membrane-associated RNA degradation protein isoform X5

    5. XM_008758816.4 → XP_008757038.1  endoplasmic reticulum membrane-associated RNA degradation protein isoform X4

      Conserved Domains (1) summary
      pfam13910
      Location:133 → 233
      DUF4209; Domain of unknown function (DUF4209)

    6. XM_063266202.1 → XP_063122272.1  endoplasmic reticulum membrane-associated RNA degradation protein isoform X7

    7. XM_006227975.5 → XP_006228037.1  endoplasmic reticulum membrane-associated RNA degradation protein isoform X3

      See identical proteins and their annotated locations for XP_006228037.1

      UniProtKB/TrEMBL
      A0A8I6A0K4
      Conserved Domains (1) summary
      pfam13910
      Location:7 → 79
      DUF4209; Domain of unknown function (DUF4209)

    8. XM_006227974.4 → XP_006228036.1  endoplasmic reticulum membrane-associated RNA degradation protein isoform X3

      See identical proteins and their annotated locations for XP_006228036.1

      UniProtKB/TrEMBL
      A0A8I6A0K4
      Conserved Domains (1) summary
      pfam13910
      Location:7 → 79
      DUF4209; Domain of unknown function (DUF4209)

    9. XM_063266215.1 → XP_063122285.1  endoplasmic reticulum membrane-associated RNA degradation protein isoform X10

    10. XM_008758817.4 → XP_008757039.1  endoplasmic reticulum membrane-associated RNA degradation protein isoform X6

      Conserved Domains (1) summary
      pfam13910
      Location:1 → 36
      DUF4209; Domain of unknown function (DUF4209)

    11. XM_017589901.3 → XP_017445390.1  endoplasmic reticulum membrane-associated RNA degradation protein isoform X9

      Conserved Domains (1) summary
      pfam13910
      Location:58 → 144
      DUF4209; Domain of unknown function (DUF4209)

    RNA

    1. XR_010054030.1 RNA Sequence

    2. XR_005498072.2 RNA Sequence

    3. XR_005498073.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001037207.1: Suppressed sequence

      Description
      NM_001037207.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: C6orf70 (GeneID:55780).
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3B8R1.2 GenPept UniProtKB/Swiss-Prot:Q3B8R1

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