Brf2 BRF2 general transcription factor 3B subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Brf2provided by RGD
Official Full Name: BRF2 general transcription factor 3B subunitprovided by RGD
Primary source: RGD:1308817
See related: EnsemblRapid:ENSRNOG00000012739 AllianceGenome:RGD:1308817
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable RNA polymerase II general transcription initiation factor activity; RNA polymerase III type 3 promoter sequence-specific DNA binding activity; and TBP-class protein binding activity. Predicted to be involved in cellular response to oxidative stress and regulation of transcription by RNA polymerase III. Predicted to be part of transcription factor TFIIIB complex and transcription preinitiation complex. Predicted to be active in nucleus. Orthologous to human BRF2 (BRF2 RNA polymerase III transcription initiation factor subunit). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 95.1), Lung (RPKM 81.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (71626146..71635909)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (64928334..64933057)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (69089955..69094678)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH141595 (e-PCR)
- UniSTS:223589

BF390610 (e-PCR)
- UniSTS:249511

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA polymerase II general transcription initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase III type 3 promoter sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase III type 3 promoter sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables TBP-class protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase III	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase III	ISS Inferred from Sequence or Structural Similarity more info
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in transcription preinitiation complex assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFIIIB complex	ISO Inferred from Sequence Orthology more info
part_of transcription factor TFIIIB complex	ISS Inferred from Sequence or Structural Similarity more info
part_of transcription preinitiation complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transcription factor IIIB 50 kDa subunit

Names: B-related factor 2; BRF-2; BRF2, RNA polymerase III transcription initiation factor 50 subunit; BRF2, RNA polymerase III transcription initiation factor subunit; BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024773.1 → NP_001019944.1 transcription factor IIIB 50 kDa subunit

See identical proteins and their annotated locations for NP_001019944.1

Status: PROVISIONAL

Source sequence(s)

BC097435

UniProtKB/Swiss-Prot

Q4V8D6

UniProtKB/TrEMBL

A0A8I5ZJ74, A6IVY0

Related

ENSRNOP00000017324.4, ENSRNOT00000017324.8

Conserved Domains (2) summary

COG1405
Location:6 → 244

SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]

pfam08271
Location:6 → 37

TF_Zn_Ribbon; TFIIB zinc-binding

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

71626146..71635909

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063275441.1 → XP_063131511.1 transcription factor IIIB 50 kDa subunit isoform X1

UniProtKB/Swiss-Prot

Q4V8D6

UniProtKB/TrEMBL

A0A8I5ZJ74, A6IVY0