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    Cds CDP-diacylglycerol synthase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43950, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdsprovided by FlyBase
    Official Full Name
    CDP-diacylglycerol synthaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010350
    Locus tag
    Dmel_CG7962
    See related
    AllianceGenome:FB:FBgn0010350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cds; CDS; cdsA; CdsA; CG7962; Dmel\CG7962; eye-cds; eye-CDS
    Summary
    Enables phosphatidate cytidylyltransferase activity. Involved in several processes, including regulation of lipid biosynthetic process; sperm individualization; and thermotaxis. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head; adult heart; eye photoreceptor cell; and photoreceptor. Orthologous to human CDS1 (CDP-diacylglycerol synthase 1) and CDS2 (CDP-diacylglycerol synthase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cds in Genome Data Viewer
    Location:
    66B7-66B7; 3-22 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8127762..8131675)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8120862..8124775)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene lariat debranching enzyme Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L36 Neighboring gene Ubiquitin-like activating enzyme 2 Neighboring gene Senataxin Neighboring gene mutagen-sensitive 301 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lipid storage regulator CdsA is essential for Drosophila metamorphosis. Liu Y, et al. J Genet Genomics, 2019 Apr 20. PMID 31072795
    2. Signal transduction. Phospholipids in action. Hurley JB. Nature, 1995 Jan 19. PMID 7816126
    3. Calcium influx via TRP channels is required to maintain PIP2 levels in Drosophila photoreceptors. Hardie RC, et al. Neuron, 2001 Apr. PMID 11343651
    4. shibire's enhancer is cancer's suppressor. Deitcher D. Trends Neurosci, 2001 Nov. PMID 11672786
    5. Reduced expression of CDP-DAG synthase changes lipid composition and leads to male sterility in Drosophila. Laurinyecz B, et al. Open Biol, 2016 Jan. PMID 26791243, Free PMC Article

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CdsA is essential for Drosophila metamorphosis
      Title: Lipid storage regulator CdsA is essential for Drosophila metamorphosis.
    2. The results of lipidomic and genetic analyses of the CdsA mutant highlight the importance of correct lipid composition during sperm development and show that phosphatidic acid levels are crucial in late stages of spermatogenesis.
      Title: Reduced expression of CDP-DAG synthase changes lipid composition and leads to male sterility in Drosophila.
    3. Overexpressing CdsA rescues the fat storage and cell growth phenotypes of insulin pathway mutants, suggesting that CdsA coordinates cell/tissue growth and lipid storage through the insulin pathway.
      Title: CDP-diacylglycerol synthetase coordinates cell growth and fat storage through phosphatidylinositol metabolism and the insulin pathway.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatidate cytidylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidate cytidylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidate cytidylyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CDP-diacylglycerol biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in G protein-coupled opsin signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of triglyceride biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phototransduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phototransduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phototransduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm individualization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in terminal branching, open tracheal system HMP PubMed 
    involved_in thermotaxis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CDP-diacylglycerol synthase
    Names
    CDP diglyceride synthetase
    CDP-DAG synthase
    CDP-diacylglycerol synthetase
    CDS-diacylglycerol synthase
    CG7962-PA
    CG7962-PB
    Cds-PA
    Cds-PB
    cytidine diphosphate (CDP)-DAG synthase
    diacyl-glycerol-synthetase
    winded
    NP_001286976.1
    NP_524661.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8127762..8131675
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300047.1 → NP_001286976.1  CDP-diacylglycerol synthase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286976.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P56079, Q9VSE0
      UniProtKB/TrEMBL
      H9ZJM9, X2JC55
      Conserved Domains (1) summary
      cl21502
      Location:120 → 438
      CTP_transf_1; Cytidylyltransferase family

    2. NM_079922.4 → NP_524661.1  CDP-diacylglycerol synthase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524661.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P56079, Q9VSE0
      UniProtKB/TrEMBL
      H9ZJM9, X2JC55
      Related
      FBpp0076411
      Conserved Domains (1) summary
      cl21502
      Location:120 → 438
      CTP_transf_1; Cytidylyltransferase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P56079.2 P56079
    X2JC55 X2JC55

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