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    Gdap1 Gdap1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38597, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gdap1provided by FlyBase
    Official Full Name
    Gdap1provided by FlyBase
    Primary source
    FLYBASE:FBgn0035587
    Locus tag
    Dmel_CG4623
    See related
    AllianceGenome:FB:FBgn0035587
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4623; dGdap1; Dmel\CG4623; Gdap; GDAP1
    Summary
    Involved in mitochondrion organization. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial outer membrane. Is expressed in several structures, including Malpighian tubule; adult gut; adult head; embryonic epipharynx; and gut section. Used to study Charcot-Marie-Tooth disease. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; Charcot-Marie-Tooth disease axonal type 2C; Charcot-Marie-Tooth disease axonal type 2K; Charcot-Marie-Tooth disease recessive intermediate A; and Charcot-Marie-Tooth disease type 4A. Orthologous to human GDAP1 (ganglioside induced differentiation associated protein 1) and GDAP1L1 (ganglioside induced differentiation associated protein 1 like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gdap1 in Genome Data Viewer
    Location:
    64C7-64C7; 3-13 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5141953..5144317)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5135053..5137417)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Threonyl-carbamoyl synthesis 5 Neighboring gene Charged multivesicular body protein 2b Neighboring gene long non-coding RNA:CR45985 Neighboring gene Dehydrogenase/reductase 4 Neighboring gene Fat storage inducing transmembrane protein Neighboring gene Alanyl-tRNA synthetase, mitochondrial Neighboring gene XPG-like endonuclease Neighboring gene Signal recognition particle 54k

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Drosophila model of GDAP1 function reveals the involvement of insulin signalling in the mitochondria-dependent neuromuscular degeneration. López Del Amo V, et al. Biochim Biophys Acta Mol Basis Dis, 2017 Mar. PMID 28065847
    2. Mitochondrial defects and neuromuscular degeneration caused by altered expression of Drosophila Gdap1: implications for the Charcot-Marie-Tooth neuropathy. López Del Amo V, et al. Hum Mol Genet, 2015 Jan 1. PMID 25122658
    3. Drp1-mediated mitochondrial fission regulates calcium and F-actin dynamics during wound healing. Ponte S, et al. Biol Open, 2020 May 3. PMID 32184231, Free PMC Article
    4. The genetic basis of adaptation to copper pollution in Drosophila melanogaster. Everman ER, et al. Front Genet, 2023. PMID 37082199, Free PMC Article
    5. Evolutionary and structural analyses of GDAP1, involved in Charcot-Marie-Tooth disease, characterize a novel class of glutathione transferase-related genes. Marco A, et al. Mol Biol Evol, 2004 Jan. PMID 14595091

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results revealed that both up- and down-regulation of Gdap1 results in an early systemic inactivation of the insulin pathway before the onset of neuromuscular degeneration, followed by an accumulation of carbohydrates and an increase in the beta-oxidation of lipids.
      Title: A Drosophila model of GDAP1 function reveals the involvement of insulin signalling in the mitochondria-dependent neuromuscular degeneration.
    2. Results show that CG4623 gene, Drosophila ortholog of human GDAP1 has a function related to mitochondrial dynamics and its expression de-regulation can result in neuronal degeneration and in autonomous muscle degeneration without motor nerve involvement.
      Title: Mitochondrial defects and neuromuscular degeneration caused by altered expression of Drosophila Gdap1: implications for the Charcot-Marie-Tooth neuropathy.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial fission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial fission ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in mitochondrial fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Gdap1
    Names
    CG4623-PA
    CG4623-PB
    CG4623-PC
    GDAP1 ortholog
    Gdap1-PA
    Gdap1-PB
    Gdap1-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      5141953..5144317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139688.4 → NP_647945.1  Gdap1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647945.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VRJ3
      Related
      FBpp0076870
      Conserved Domains (3) summary
      COG0625
      Location:30 → 290
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd00570
      Location:28 → 100
      GST_N_family; Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic ...
      cl02776
      Location:178 → 285
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    2. NM_001300010.1 → NP_001286939.1  Gdap1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286939.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JAP0
      Conserved Domains (3) summary
      COG0625
      Location:30 → 290
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd00570
      Location:28 → 100
      GST_N_family; Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic ...
      cl02776
      Location:178 → 285
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    3. NM_001274508.1 → NP_001261437.1  Gdap1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261437.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PBQ8
      Conserved Domains (3) summary
      COG0625
      Location:30 → 289
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd00570
      Location:28 → 100
      GST_N_family; Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic ...
      cl02776
      Location:177 → 284
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PBQ8 M9PBQ8
    Q9VRJ3 Q9VRJ3
    X2JAP0 X2JAP0

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